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The Enamovirus P0 protein is a silencing suppressor which inhibits local and systemic RNA silencing through AGO1 degradation.
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- Additional Information
- Source:
Publisher: Academic Press Country of Publication: United States NLM ID: 0110674 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-0341 (Electronic) Linking ISSN: 00426822 NLM ISO Abbreviation: Virology Subsets: MEDLINE
- Publication Information:
Original Publication: New York, Academic Press.
- Subject Terms:
- Abstract:
The P0 protein of poleroviruses and P1 protein of sobemoviruses suppress the plant's RNA silencing machinery. Here we identified a silencing suppressor protein (SSP), P0(PE), in the Enamovirus Pea enation mosaic virus-1 (PEMV-1) and showed that it and the P0s of poleroviruses Potato leaf roll virus and Cereal yellow dwarf virus have strong local and systemic SSP activity, while the P1 of Sobemovirus Southern bean mosaic virus supresses systemic silencing. The nuclear localized P0(PE) has no discernable sequence conservation with known SSPs, but proved to be a strong suppressor of local silencing and a moderate suppressor of systemic silencing. Like the P0s from poleroviruses, P0(PE) destabilizes AGO1 and this action is mediated by an F-box-like domain. Therefore, despite the lack of any sequence similarity, the poleroviral and enamoviral SSPs have a conserved mode of action upon the RNA silencing machinery.
(Copyright © 2012 Elsevier Inc. All rights reserved.)
- Accession Number:
0 (AGO1 protein, Arabidopsis)
0 (Arabidopsis Proteins)
0 (Argonaute Proteins)
0 (Repressor Proteins)
0 (Viral Proteins)
- Publication Date:
Date Created: 20120225 Date Completed: 20120507 Latest Revision: 20220310
- Publication Date:
20221213
- Accession Number:
10.1016/j.virol.2012.01.026
- Accession Number:
22361475
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