Insulin and hypertonic glucose in the management of aseptic fat liquefaction of post-surgical incision: a meta-analysis and systematic review.

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  • Additional Information
    • Source:
      Publisher: Blackwell Pub Country of Publication: England NLM ID: 101230907 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1742-481X (Electronic) Linking ISSN: 17424801 NLM ISO Abbreviation: Int Wound J Subsets: MEDLINE
    • Publication Information:
      Original Publication: Oxford : Blackwell Pub., c2004-
    • Subject Terms:
      Fat Necrosis/*drug therapy ; Glucose Solution, Hypertonic/*administration & dosage ; Hypoglycemic Agents/*administration & dosage ; Insulin/*administration & dosage ; Postoperative Complications/*drug therapy ; Wounds and Injuries/*drug therapy; Cost-Benefit Analysis ; Drug Combinations ; Glucose Solution, Hypertonic/adverse effects ; Glucose Solution, Hypertonic/economics ; Humans ; Hypoglycemic Agents/adverse effects ; Hypoglycemic Agents/economics ; Injections, Subcutaneous ; Insulin/adverse effects ; Insulin/economics ; Randomized Controlled Trials as Topic ; Wound Healing/drug effects
    • Abstract:
      A meta-analysis and systematic review assessing randomised controlled trials (RCTs) was sought to determine whether subcutaneous injection of insulin with hypertonic glucose promotes healing in postoperative incisions with aseptic fat liquefaction. We searched the Cochrane library, Pubmed, EMBASE, National Science Digital Library (NSDL) and China Biological Medicine Database (CBMdisc) for literature published from 1 January 1990 to 30 September 2011. RCTs that evaluated subcutaneous injection of insulin with hypertonic glucose as a treatment for postoperative wound with fat liquefaction were sought. Wound healing was the primary endpoint. Jadad score and Cochrane Collaboration's tool were used for assessing quality of studies and risk of bias. We abstracted data regarding time to wound healing, cost and adverse effects. The random-effects inverse variance model was used for all analyses using weighted mean difference and 95% confidence interval. Eight trials (414 participants) were identified that met the inclusion criteria. Subcutaneous injection of insulin with hypertonic glucose significantly reduces time to healing by 6·33 days compared with conventional drainage, with less cost. There was no report concerning adverse effects. Subcutaneous injection of insulin with hypertonic glucose may improve the healing process in postoperative wounds with aseptic fat liquefaction.
      (© 2012 The Authors. International Wound Journal © 2012 Blackwell Publishing Ltd and Medicalhelplines.com Inc.)
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    • Accession Number:
      0 (Drug Combinations)
      0 (Glucose Solution, Hypertonic)
      0 (Hypoglycemic Agents)
      0 (Insulin)
    • Publication Date:
      Date Created: 20120214 Date Completed: 20130704 Latest Revision: 20240331
    • Publication Date:
      20240331
    • Accession Number:
      PMC7950496
    • Accession Number:
      10.1111/j.1742-481X.2012.00949.x
    • Accession Number:
      22325039