Plasma Cell Dyscrasia with Kappa Light-chain Crystals in Proximal Tubular Cells: A Histological, Immunofluorescent, and Ultrastructural Study.

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    • Subject Terms:
      CRYSTALS; ELECTRON microscopy; MESONS; PLASMA cell diseases; ULTRASTRUCTURE (Biology)
    • Abstract:
      This is a case report of a 56-year-old man with plasma cell dyscrasia who presented with proximal tubulopathy manifested as kappa light-chain crystal deposition in the proximal convoluted tubular cells. This was associated with mild cellular damage. The crystals were seen as negative images with the hematoxylin–eosin and periodic acid–Schiff (PAS) stains. They were identified as kappa light-chains by immunofluorescent imaging and confirmed by immunoelectron microscopy. Ultrastructurally, the crystals appear to be located within lysosomes. No deposits of light-chains were seen elsewhere in the kidney biopsy. [ABSTRACT FROM AUTHOR]