Nef-induced CD4 degradation: A diacidic-based motif in Nef functions as a lysosomal targeting...

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    • Abstract:
      Demonstrates that the Nef protein of primate lentiviruses targets internalized CD4 molecules for degradation by acting as a connector between CD4 and the beta subunit of COPI coatomers in endosomes. Beta-COP recruitment and routing to lysosomes; Endosomal sorting.