[Opportunities for effective skin regeneration by topical stimulation of immunity].

Publisher: Pediatr Country of Publication: Russia (Federation) NLM ID: 9215641 Publication Model: Print Cited Medium: Print ISSN: 0869-6047 (Print) Linking ISSN: 08696047 NLM ISO Abbreviation: Vestn Ross Akad Med Nauk Subsets: MEDLINE

Publication: <2016- > : Moskva : Pediatr
Original Publication: Moskva : Meditsina, 1992-

Lipopolysaccharides*/administration & dosage ; Lipopolysaccharides*/immunology ; Wound Healing*/drug effects ; Wound Healing*/immunology ; Wounds and Injuries*/complications ; Wounds and Injuries*/immunology ; Wounds and Injuries*/therapy; Cicatrix, Hypertrophic/*prevention & control ; Tensile Strength/*drug effects; Administration, Topical ; Animals ; Cicatrix, Hypertrophic/etiology ; Cicatrix, Hypertrophic/immunology ; Immunity, Innate ; Immunologic Factors/administration & dosage ; Immunologic Factors/immunology ; Mice ; Skin/injuries ; Toll-Like Receptors/metabolism ; Treatment Outcome

A murine model of incisional wound was used to evaluate effect of topical application of purified bacterial lipopolysaccharide on the wound healing process. Thirty five ICR mice were used in the study. It was shown that bacterial lipopolysaccharide is a strong promotor of wound healing. It increases tensile strength, accelerates completion of the inflammatory process, stimulates collagen deposition and early remodeling.

0 (Immunologic Factors)
0 (Lipopolysaccharides)
0 (Toll-Like Receptors)

Date Created: 20111216 Date Completed: 20120117 Latest Revision: 20161020

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