Effect of DETA-NONOate and papaverine on vasodilation of human internal mammary artery.

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  • Additional Information
    • Source:
      Publisher: Canadian Science Publishing Country of Publication: Canada NLM ID: 0372712 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1205-7541 (Electronic) Linking ISSN: 00084212 NLM ISO Abbreviation: Can J Physiol Pharmacol Subsets: MEDLINE
    • Publication Information:
      Publication: 2011- : Ottawa, ON : Canadian Science Publishing
      Original Publication: Ottawa, National Research Council of Canada.
    • Subject Terms:
      Mammary Arteries/*drug effects ; Nitroso Compounds/*pharmacology ; Papaverine/*pharmacology ; Vasodilation/*drug effects ; Vasodilator Agents/*pharmacology; Aged ; Cardiotonic Agents/adverse effects ; Humans ; Male ; Mammary Arteries/physiology ; Middle Aged ; Muscle, Smooth, Vascular/drug effects ; Muscle, Smooth, Vascular/physiology ; Nitric Oxide/metabolism ; Phenylephrine/adverse effects
    • Abstract:
      In this study, the relaxatory effect of DETA-NONOate is compared with that of papaverine on isolated human internal mammary artery. We investigated the inhibitory effects of DETA-NONOate and papaverine on phenylephrine-induced contractile response in internal mammary artery segments. The internal mammary artery segments, taken from methodologically matched patients who underwent coronary artery bypass grafting, were prepared, placed in an organ bath, and contracted with phenylephrine (10(-9) to 10(-4) mol/L) to investigate their relaxatory response to DETA-NONOate or papaverine. Phenylephrine dose-response contraction was obtained after 1, 2, and 3 h in segments pre-incubated with DETA-NONOate or papaverine for 30 min. The EC50 that presented for internal mammary artery segments incubated with DETA-NONOate was 3.523 ± 1.2696 × 10(-7) mol/L, and for papaverine was 3.467 ± 1.2145 × 10(-6) mol/L. In segments pre-incubated with DETA-NONOate, the contractile response to phenylephrine was suppressed in the first 2 h post-incubation, compared with control responsive groups (p < 0.05), but this inhibition was revoked after 3 h post-incubation. We showed that DETA-NONOate has a more significant relaxative effect by comparison with papaverine; moreover, continuous and long-lasting nitric oxide production by DETA-NONOate might be of great importance for the outcome from coronary artery bypass grafting, when internal mammary artery is used as a conduit.
    • Accession Number:
      0 (Cardiotonic Agents)
      0 (Nitroso Compounds)
      0 (Vasodilator Agents)
      146724-94-9 (2,2'-(hydroxynitrosohydrazono)bis-ethanamine)
      1WS297W6MV (Phenylephrine)
      31C4KY9ESH (Nitric Oxide)
      DAA13NKG2Q (Papaverine)
    • Publication Date:
      Date Created: 20111126 Date Completed: 20141212 Latest Revision: 20140416
    • Publication Date:
      20240829
    • Accession Number:
      10.1139/y11-092
    • Accession Number:
      22117187