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"Intravascular lymphomatosis" (angioendotheliomatosis): evidence for a T-cell origin in two cases.
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- Additional Information
- Source:
Publisher: W B Saunders Country of Publication: United States NLM ID: 9421547 Publication Model: Print Cited Medium: Print ISSN: 0046-8177 (Print) Linking ISSN: 00468177 NLM ISO Abbreviation: Hum Pathol Subsets: MEDLINE
- Publication Information:
Publication: Philadelphia, PA : W B Saunders
Original Publication: Philadelphia, W B. Saunders Co.
- Subject Terms:
Hemangioendothelioma/
*pathology ;
Neoplasms, Vascular Tissue/
*pathology;
Aged ;
Aged, 80 and over ;
Antigens, CD/
immunology ;
Blotting, Southern ;
Cell Transformation, Neoplastic/
immunology ;
Cell Transformation, Neoplastic/
pathology ;
Cell Transformation, Neoplastic/
ultrastructure ;
Endothelium, Vascular/
pathology ;
Female ;
Gene Rearrangement, T-Lymphocyte/
immunology ;
Hemangioendothelioma/
immunology ;
Hemangioendothelioma/
ultrastructure ;
Humans ;
Immunohistochemistry ;
Microscopy, Electron ;
Neoplasms, Vascular Tissue/
immunology ;
Neoplasms, Vascular Tissue/
metabolism ;
Stem Cells/
immunology ;
Stem Cells/
pathology ;
Stem Cells/
ultrastructure ;
T-Lymphocytes/
immunology ;
T-Lymphocytes/
pathology ;
T-Lymphocytes/
ultrastructure - Abstract:
Intravascular lymphomatosis (IL) is a rare and potentially fatal multifocal intravascular proliferative disorder, most often involving the skin and the central nervous system. Originally considered an endothelial disorder, IL has recently been reclassified as an angiotropic lymphoma, most often of B-cell origin. We report immunocytochemical and ultrastructural findings in two patients with IL, both representing angiotropic T-cell lymphomas. In one patient, lesional tissue was examined by Southern blot analysis and monoclonal T-cell receptor rearrangement was found. As an additional feature in one patient, a myelosuppressive serum factor was demonstrated in peripheral blood progenitor cell cultures as the cause of underlying chronic anemia and leukopenia; this factor is thought to be a cytokine product of the lymphoma cells.
- Accession Number:
0 (Antigens, CD)
- Publication Date:
Date Created: 19901001 Date Completed: 19901102 Latest Revision: 20190722
- Publication Date:
20240829
- Accession Number:
10.1016/0046-8177(90)90255-4
- Accession Number:
2210728
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