[Effects of huanglian jiedu decoction on free radicals metabolism and pathomorphism of the hippocampus in App/PS1 double transgenic mice].

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  • Author(s): Qiu X;Qiu X; Chen GH; Wang T
  • Source:
    Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine [Zhongguo Zhong Xi Yi Jie He Za Zhi] 2011 Oct; Vol. 31 (10), pp. 1379-82.
  • Publication Type:
    English Abstract; Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
  • Language:
    Chinese
  • Additional Information
    • Source:
      Publisher: Gai yan jiu yuan Country of Publication: China NLM ID: 9211576 Publication Model: Print Cited Medium: Print ISSN: 1003-5370 (Print) Linking ISSN: 10035370 NLM ISO Abbreviation: Zhongguo Zhong Xi Yi Jie He Za Zhi Subsets: MEDLINE
    • Publication Information:
      Publication: Beijing : Gai yan jiu yuan
      Original Publication: Beijing : Gai yan jiu yuan, 1992-
    • Subject Terms:
      Alzheimer Disease/*metabolism ; Drugs, Chinese Herbal/*pharmacology ; Hippocampus/*drug effects; Alzheimer Disease/pathology ; Animals ; Free Radicals/metabolism ; Hippocampus/pathology ; Male ; Mice ; Mice, Transgenic
    • Abstract:
      Objective: To observe the effects of Huanglian Jiedu Decoction (HLJDT) on the metabolism of free radicals, the morphology and histopathology of hippocampal CA1 neurons in PS1/APP double transgenic mice of Alzheimer's disease (AD), and to study its possible mechanisms, thus providing experimental evidence for treating AD by HLJDT.
      Methods: The APP/PS1 double transgenic mouse model was used. Mice were randomly divided into five groups, i. e., the model control group, the positive control group (Aricept), high-, middle-, and low-dose HLJDT group (at the daily dose of 865 mg*kg(-1), 433 mg*kg(-1), and 216 mg*kg(-1), respectively). Corresponding medication was daily given by gastrogavage. Seven months later superoxide dismutase (SOD) and malondialdehyde (MDA) were detected at the ten-month old mice, thus observing the effects on the morphology of CA1 hippocampal neurons and the senile plaques (SP).
      Results: HLJDT and Aricept could obviously increase the SOD contents and lower the MDA contents (P<0.05), attenuate the destroy of neurocytes and the formation of SP, effectively hinder the degeneration of hippocampal neurons. Better results were obtained in the middle-dose HLJDT group than in the positive control group (P<0.05).
      Conclusion: The mechanism of HLJDT in treating AD might be possibly correlated with improving anti-oxygenation, protecting hippocampal neurocytes, and reducing the formation of SP.
    • Accession Number:
      0 (Drugs, Chinese Herbal)
      0 (Free Radicals)
      0 (huanglian)
    • Publication Date:
      Date Created: 20111122 Date Completed: 20130801 Latest Revision: 20161018
    • Publication Date:
      20240829
    • Accession Number:
      22097209