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[A case of intractable pneumothorax in a patient with pulmonary adenocarcinoma during bevacizumab-containing chemotherapy].
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- Author(s): Tamura T;Tamura T; Tamura S; Nasu H; Fujimoto T; Kinoshita T
- Source:
Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society [Nihon Kokyuki Gakkai Zasshi] 2011 Sep; Vol. 49 (9), pp. 702-6.- Publication Type:
Case Reports; English Abstract; Journal Article- Language:
Japanese - Source:
- Additional Information
- Source: Publisher: Dō Gakkai Country of Publication: Japan NLM ID: 9808802 Publication Model: Print Cited Medium: Print ISSN: 1343-3490 (Print) Linking ISSN: 13433490 NLM ISO Abbreviation: Nihon Kokyuki Gakkai Zasshi Subsets: MEDLINE
- Publication Information: Original Publication: Tōkyō : Dō Gakkai,
- Subject Terms: Adenocarcinoma/*drug therapy ; Angiogenesis Inhibitors/*adverse effects ; Antibodies, Monoclonal, Humanized/*adverse effects ; Lung Neoplasms/*drug therapy ; Pneumothorax/*chemically induced; Aged ; Antibodies, Monoclonal, Humanized/administration & dosage ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Bevacizumab ; Female ; Humans
- Abstract: The patient was a 70-year-old woman. She was admitted to our hospital complaining of fever and dyspnea. Chest CT scan showed a 50 x 30-mm tumorous shadow in S6 of the left lung and honeycomb lung in both lower lobes. As the result of cytodiagnosis with ultrasonic echo, adenocarcinoma was diagnosed. Clinical stage was IIIA (T3N2M0). We selected carboplatin and paclitaxel with bevacizumab as first-line chemotherapy, but at 7 days after the initiating it, the chest X-ray showed left pneumothorax. A chest drainage tube was placed in the left thoracic cavity. The patient was treated repeatedly pleurodesis with minocycline and OK-432. The pneumothorax required 3 weeks to cure. We selected carboplatin and paclitaxel without bevacizumab for the second course, and the pneumothorax did not recur. Pneumothorax was a serious adverse event associated with bevacizumab-containing chemotherapy. It is necessary to be aware of the possibility of pneumothorax when we treat lung adenocarcinoma with bevacizumab-containing chemotherapy.
- Accession Number: 0 (Angiogenesis Inhibitors)
0 (Antibodies, Monoclonal, Humanized)
2S9ZZM9Q9V (Bevacizumab) - Publication Date: Date Created: 20111112 Date Completed: 20111216 Latest Revision: 20151119
- Publication Date: 20240829
- Accession Number: 22073619
- Source:
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