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Life-threatening thrombocytosis following GCSF treatment in a case of clozapine-induced agranulocytosis.
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- Author(s): Dihingia S;Dihingia S; Deka K; Bhuyan D; Mondal SK
- Source:
General hospital psychiatry [Gen Hosp Psychiatry] 2012 May-Jun; Vol. 34 (3), pp. 320.e1-2. Date of Electronic Publication: 2011 Oct 21.
- Publication Type:
Case Reports; Journal Article
- Language:
English
- Additional Information
- Source:
Publisher: Elsevier/North-Holland Country of Publication: United States NLM ID: 7905527 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7714 (Electronic) Linking ISSN: 01638343 NLM ISO Abbreviation: Gen Hosp Psychiatry Subsets: MEDLINE
- Publication Information:
Original Publication: New York, Elsevier/North-Holland.
- Subject Terms:
- Abstract:
Clozapine was introduced in European market in 1972 as an effective treatment for schizophrenia without extrapyramidal side effects. Within a short while, the clozapine story virtually came to a halt following detection of life-threatening neutropenia and agranulocytosis. Judicial use of granulocyte colony stimulating factor (GCSF) can be life saving with infrequent side effects in these cases. Here we are presenting a case of clozapine induced agranulocytosis managed with GCSF but had transient but life-threatening thrombocytosis, a very uncommon complication of GCSF therapy. Expression of GCSF receptors on the surface of megakaryocytic lineage is thought to be the cause of this unusual phenomenon.
(Copyright © 2012 Elsevier Inc. All rights reserved.)
- Accession Number:
143011-72-7 (Granulocyte Colony-Stimulating Factor)
J60AR2IKIC (Clozapine)
- Publication Date:
Date Created: 20111025 Date Completed: 20120927 Latest Revision: 20131121
- Publication Date:
20231215
- Accession Number:
10.1016/j.genhosppsych.2011.09.011
- Accession Number:
22018773
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