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Racial differences in measures of obesity and risk of colon adenoma.
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- Author(s): Thompson CL;Thompson CL; Berger NA; Chak A; Li L
- Source:
Obesity (Silver Spring, Md.) [Obesity (Silver Spring)] 2012 Mar; Vol. 20 (3), pp. 673-7. Date of Electronic Publication: 2011 Oct 13.- Publication Type:
Journal Article; Research Support, N.I.H., Extramural- Language:
English - Source:
- Additional Information
- Source: Publisher: John Wiley & Sons Country of Publication: United States NLM ID: 101264860 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1930-739X (Electronic) Linking ISSN: 19307381 NLM ISO Abbreviation: Obesity (Silver Spring) Subsets: MEDLINE
- Publication Information: Publication: 2013- : Malden, MA : John Wiley & Sons
Original Publication: Silver Spring, MD : NAASO, the Obesity Society, c2006- - Subject Terms: Body Fat Distribution* ; Waist Circumference*/ethnology; Adenomatous Polyposis Coli/*ethnology ; Black or African American/*statistics & numerical data ; Obesity/*ethnology ; White People/*statistics & numerical data; Adenomatous Polyposis Coli/etiology ; Body Mass Index ; Female ; Humans ; Male ; Middle Aged ; Obesity/complications ; Odds Ratio ; Prospective Studies ; Risk Assessment ; Risk Factors ; Sex Distribution ; United States/epidemiology ; Waist-Hip Ratio
- Abstract: Obesity is an established risk factor for several malignancies. However, the specific measurement of obesity most relevant to colon neoplasia is still debated, and evidence has suggested gender and racial differences in this measurement. In this study, we sought to compare which measurement--BMI, waist circumference (WC), waist-to-hip ratio (WHR) or waist-to-height ratio (WHtR)--is most strongly associated with development of colon adenomas, a precursor of colon cancer, and to investigate differences in this association between racial groups. We confirmed the strong association between WHR, as a measure of central obesity, and development of colon neoplasia. In our overall analysis, patients in the highest WHR quartile showed a substantial increase in risk of colon adenomas compared to patients in the lowest WHR quartile (odds ratio (OR) = 1.82, 95% confidence interval (CI): 1.12-2.71, P(trend) = 0.0017). In stratified analyses, we noted that strongly associated obesity measures in European Americans were WC (OR = 2.38, 95% CI = 1.45-3.92, P(trend) = 0.0004) and BMI (OR = 2.18, 95% CI = 1.37-3.49, P(trend) = 0.0015), whereas in African Americans, WHR was the strongest and the only obesity measure statistically significantly associated with adenoma risk (OR = 2.12, 95% CI = 1.05-4.30, P(trend) = 0.025). Our data highlight the importance of obesity in the development of early colon neoplasia and suggest substantial racial differences in the measures of obesity most strongly associated with risk of colon adenomas.
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N Engl J Med. 2008 Nov 13;359(20):2105-20. (PMID: 19005195) - Grant Information: K22 CA120545 United States CA NCI NIH HHS; P30 CA043703 United States CA NCI NIH HHS; U54 CA116867 United States CA NCI NIH HHS; R01 CA136726 United States CA NCI NIH HHS; K07 CA136758 United States CA NCI NIH HHS
- Publication Date: Date Created: 20111015 Date Completed: 20120612 Latest Revision: 20240404
- Publication Date: 20240404
- Accession Number: PMC4301956
- Accession Number: 10.1038/oby.2011.295
- Accession Number: 21996657
- Source:
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