Improved blood compatibility of Mg-1.0Zn-1.0Ca alloy by micro-arc oxidation.

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  • Author(s): Zhang BP;Zhang BP; Qiu H; Wang DW; Liu YQ; Bi ZG
  • Source:
    Journal of biomedical materials research. Part A [J Biomed Mater Res A] 2011 Nov; Vol. 99 (2), pp. 166-72. Date of Electronic Publication: 2011 Aug 16.
  • Publication Type:
    Journal Article; Research Support, Non-U.S. Gov't
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: John Wiley & Sons Country of Publication: United States NLM ID: 101234237 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1552-4965 (Electronic) Linking ISSN: 15493296 NLM ISO Abbreviation: J Biomed Mater Res A Subsets: MEDLINE
    • Publication Information:
      Original Publication: Hoboken, NJ : John Wiley & Sons, c2002-
    • Subject Terms:
      Alloys/*chemistry ; Alloys/*metabolism ; Biocompatible Materials/*chemistry ; Biocompatible Materials/*metabolism ; Calcium/*chemistry ; Magnesium/*chemistry; Animals ; Blood Coagulation ; Bone Marrow Cells/cytology ; Bone Marrow Cells/physiology ; Calcium/metabolism ; Cells, Cultured ; Ceramics/chemistry ; Corrosion ; Hemolysis ; Humans ; Magnesium/metabolism ; Male ; Materials Testing ; Mesenchymal Stem Cells/cytology ; Mesenchymal Stem Cells/physiology ; Oxidation-Reduction ; Platelet Aggregation ; Rats ; Rats, Sprague-Dawley ; Surface Properties
    • Abstract:
      Magnesium and its alloys have been used in the recent development of lightweight, biodegradeable implant materials. However, the corrosion properties of magnesium limit its usefulness. In a previous study, a micro-arc oxidation (MAO) method was used to modify a Mg-1.0 wt % Zn-1.0 wt % Ca alloy surface, with the purpose of improving the corrosion resistance of Mg alloys. However, the blood compatibility of MAO-treated Mg alloy is unknown. Results of cytotoxicity assays with bone marrow-derived mesenchymal stem cells showed that extracts of MAO-treated alloy significantly decreased cytotoxicity compared to titanium alloy extract. Results of blood compatibility tests showed that the MAO group had a decreased hemolytic ratio (2.25%) compared to the untreated Mg alloy group (24.58%) (p < 0.001). The MAO group showed significantly shorter prothrombin and thrombin times and significantly longer activated partial thromboplastin time than the untreated Mg alloy group. Arachidonic acid- and adenosine diphosphate-induced platelet aggregations were significantly decreased by the untreated Mg alloy extract, and they were less affected by extract of MAO-treated Mg alloy. In conclusion, MAO-treated Mg-1.0 wt % Zn-1.0 wt % Ca alloy exhibits favorable blood compatibility characteristics and may be useful in the development of magnesium implant materials.
      (Copyright © 2011 Wiley Periodicals, Inc.)
    • Comments:
      Erratum in: J Biomed Mater Res A. 2012 Oct;100(10):2861. Zhang, Bao-Ping [added]; Liu, Ying-Qun [added]; Cao, Yang [removed].
    • Accession Number:
      0 (Alloys)
      0 (Biocompatible Materials)
      I38ZP9992A (Magnesium)
      SY7Q814VUP (Calcium)
    • Publication Date:
      Date Created: 20111007 Date Completed: 20120224 Latest Revision: 20181201
    • Publication Date:
      20221213
    • Accession Number:
      10.1002/jbm.a.33134
    • Accession Number:
      21976441