[Antibiotics can ameliorate circulatory complications of liver cirrhosis].

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  • Additional Information
    • Transliterated Title:
      Antibiotika bedrer de cirkulatoriske forhold hos patienter med levercirrose.
    • Source:
      Publisher: Den Alm Danske Laegerforening Country of Publication: Denmark NLM ID: 0141730 Publication Model: Print Cited Medium: Internet ISSN: 1603-6824 (Electronic) Linking ISSN: 00415782 NLM ISO Abbreviation: Ugeskr Laeger Subsets: MEDLINE
    • Publication Information:
      Original Publication: Copenhagen : Den Alm Danske Laegerforening
    • Subject Terms:
      Anti-Bacterial Agents/*therapeutic use ; Bacterial Translocation/*drug effects ; Liver Cirrhosis/*drug therapy; Hemodynamics/drug effects ; Humans ; Hypertension, Portal/physiopathology ; Liver Cirrhosis/complications ; Liver Cirrhosis/physiopathology ; Nitric Oxide Synthase/metabolism ; Splanchnic Circulation/physiology ; Syndrome ; Vasodilation/physiology
    • Abstract:
      Livercirrhosis can be complicated by a hyperdynamic circulatory syndrome. This is due to translocation of bacteria and bacterial product (bacterial DNA and endotoxins), which stimulate the splanchnic nitric oxide synthase and leads to splanchnic vasodilatation and haemodynamic derangement. This review focuses on how broad spectrum antibiotics can ameliorate the haemodynamic consequences of bacterial translocation. It is possible that the use of broad spectrum antibiotics in the future may be used to prevent other complications of liver cirrhosis than spontaneous bacterial peritonitis and infections after gastrointestinal bleeding.
    • Accession Number:
      0 (Anti-Bacterial Agents)
      EC 1.14.13.39 (Nitric Oxide Synthase)
    • Publication Date:
      Date Created: 20110903 Date Completed: 20111102 Latest Revision: 20110902
    • Publication Date:
      20231215
    • Accession Number:
      21884664