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Design of potent selective zinc-mediated serine protease inhibitors.
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- Author(s): Katz, Bradley A.; Clark, James M.; Finer-Moore, Janet S.; Jenkins, Thomas E.; Johnson, Charles R.; Ross, Michael J.; Luong, Christine; Moore, William R.; Stroud, Robert M.
- Source:
Nature; 2/5/1998, Vol. 391 Issue 6667, p608, 5p, 2 Color Photographs, 1 Diagram, 2 Charts
- Subject Terms:
- Additional Information
- Abstract:
Reports a mode of high-affinity binding in which a zinc2+ ion is tetrahedrally coordinated between two chelating nitrogens of BABIM and two active site residues, His 57 and Ser 195. What is implied by the distinct Zn2+ coordination geometry; The suggestion that small molecule inhibitors of serine proteases with high affinity could be used as scaffolds from which to develop drugs selective for protease targets; Methods.
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