[Clinical significance of cytochrome P450 genetic polymorphism--part I. Enzymatic system of cytochrome P450 and cytochrome P450 1A2].

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  • Author(s): Duricová J;Duricová J; Grundmann M
  • Source:
    Ceska a Slovenska farmacie : casopis Ceske farmaceuticke spolecnosti a Slovenske farmaceuticke spolecnosti [Ceska Slov Farm] 2011 Jun; Vol. 60 (3), pp. 110-5.
  • Publication Type:
    English Abstract; Journal Article
  • Language:
    Slovak
  • Additional Information
    • Transliterated Title:
      Význam genetického polymorfizmu enzýmov cytochrómu P450--cast I. Enzýmový systém cytochrómu P450 a cytochróm P450 1A2.
    • Source:
      Publisher: Ceská lékarská spolecnost J. E. Purkyne Country of Publication: Czech Republic NLM ID: 9433765 Publication Model: Print Cited Medium: Print ISSN: 1210-7816 (Print) Linking ISSN: 12107816 NLM ISO Abbreviation: Ceska Slov Farm Subsets: MEDLINE
    • Publication Information:
      Original Publication: Praha : Ceská lékarská spolecnost J. E. Purkyne,
    • Subject Terms:
      Pharmacogenetics* ; Polymorphism, Genetic*; Biotransformation/*genetics ; Cytochrome P-450 CYP1A2/*genetics ; Cytochrome P-450 Enzyme System/*genetics ; Pharmaceutical Preparations/*metabolism; Humans
    • Abstract:
      Inter-individual variability in drug response is a major clinical problem. Much of the variability has been observed in drug metabolism, particularly in the enzymes of cytochrome P450. Genetic polymorphism in these enzymes may influence a patient's response to commonly prescribed drugs. The first part of this review describes the enzymatic system of cytochrome P450 and further focuses on the influence of genetic polymorphism of cytochrome P450 1A2 on drug effect.
    • Accession Number:
      0 (Pharmaceutical Preparations)
      9035-51-2 (Cytochrome P-450 Enzyme System)
      EC 1.14.14.1 (Cytochrome P-450 CYP1A2)
    • Publication Date:
      Date Created: 20110816 Date Completed: 20110908 Latest Revision: 20110815
    • Publication Date:
      20240829
    • Accession Number:
      21838140