[Serum prohepcidin and other iron metabolism parameters in healthy adults].

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  • Additional Information
    • Transliterated Title:
      Ocena stezenia prohepcydyny na tle wybranych parametrów gospodarki zelazem w surowicy krwi ludzi zdrowych.
    • Source:
      Publisher: Wydawnicto Przeglad Lekarski Country of Publication: Poland NLM ID: 19840720R Publication Model: Print Cited Medium: Print ISSN: 0033-2240 (Print) Linking ISSN: 00332240 NLM ISO Abbreviation: Przegl Lek Subsets: MEDLINE
    • Publication Information:
      Original Publication: Kraków : Wydawnicto Przeglad Lekarski
    • Subject Terms:
      Antimicrobial Cationic Peptides/*blood ; Ferritins/*blood ; Iron/*blood ; Iron, Dietary/*pharmacokinetics ; Protein Precursors/*blood; Adolescent ; Adult ; Age Factors ; Aged ; Aged, 80 and over ; Female ; Hepcidins ; Humans ; Male ; Middle Aged ; Reference Values ; Sex Characteristics ; Young Adult
    • Abstract:
      Unlabelled: Hepcidin is a newly discovered iron metabolism regulator. It decreases iron absorption from the duodenal enterocytes and inhibits its release from the reticuloendothelial macrophages. The experiments on hepcidin and its precursor--prohepcidin seem very promising and underline the need to establish the reference intervals for these proteins and define the effects of age and sex on their concentrations.
      Aim: The aim of this study was to assess the impact of age and sex on serum prohepcidin concentration in healthy adults.
      Material and Methods: The study group consisted of 79 healthy volunteers (F-29, M-50) between 18 to 88 years of age. Healthy adults were divided into three groups according to age: group 1-33 healthy volunteers aged between 18-36, group 2-20 healthy volunteers aged between 38-53, group 3- 26 healthy volunteers aged between 58-88. Prohepcidin and ferritin concentrations were determined by enzyme-linked immunosorbent assays (ELISA). Serum iron concentration was measured on Architect c8000 System.
      Results: In this work, we demonstrated that prohepcidin concentrations were significantly higher in group 3 (Me = 292,2 ng/ ml) in comparison with group 1 (Me = 150.7 ng/ml; p < 0.000001) or group 2 (Me = 118.1 ng/ml; p < 0.000001). We observed a positive correlation between age and prohepcidin concentration (R = 0.38; p = 0.001). The oldest group of volunteers also revealed significantly higher levels of ferritin and lower levels of serum iron in comparison with two groups of younger adults. Females showed significantly higher level of prohepcidin (Me = 226.51 ng/ml) than males (Me = 142.6 ng/ml; p = 0.01). We observed that females under 50 years of age had significantly higher levels of prohepcidin (Me = 290.9 ng/ml) in comparison with younger females (Me = 150.7 ng/ml; p = 0.0001), similar correlation was noticed in males (212.3 ng/ml vs 128.3 ng/ml; p = 0.007).
      Conclusions: Prohepcidin concentration increased significantly with age and was significantly higher in women than men. The results of our study show that serum prohepcidin concentration is age and sex dependent.
    • Accession Number:
      0 (Antimicrobial Cationic Peptides)
      0 (Hepcidins)
      0 (Iron, Dietary)
      0 (Protein Precursors)
      9007-73-2 (Ferritins)
      E1UOL152H7 (Iron)
    • Publication Date:
      Date Created: 20110715 Date Completed: 20111213 Latest Revision: 20131121
    • Publication Date:
      20221213
    • Accession Number:
      21751515