Chemical activation of MEK1--a redox trigger for evaluating the effects of phosphorylation.

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  • Author(s): Lamoureaux TL;Lamoureaux TL; Lee DH
  • Source:
    Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2011 Aug 14; Vol. 47 (30), pp. 8623-5. Date of Electronic Publication: 2011 Jun 30.
  • Publication Type:
    Journal Article
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 9610838 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1364-548X (Electronic) Linking ISSN: 13597345 NLM ISO Abbreviation: Chem Commun (Camb) Subsets: MEDLINE
    • Publication Information:
      Original Publication: Cambridge : Royal Society of Chemistry
    • Subject Terms:
      MAP Kinase Kinase 1/*chemistry; Antibodies/immunology ; Cysteine/chemistry ; Enzyme Activation ; MAP Kinase Kinase 1/immunology ; MAP Kinase Kinase 1/metabolism ; Oxidation-Reduction ; Phosphorylation ; Reducing Agents/chemistry ; Sulfates/chemistry
    • Abstract:
      An approach to generate mimics of phosphorylated serine proteins chemically through site-specific sulfonation of cysteine is presented. This chemical modification is reversible in the presence of reducing agent and therefore is analogous to the kinase/phosphatase system used in nature.
      (This journal is © The Royal Society of Chemistry 2011)
    • Accession Number:
      0 (Antibodies)
      0 (Reducing Agents)
      0 (Sulfates)
      0YPR65R21J (sodium sulfate)
      EC 2.7.12.2 (MAP Kinase Kinase 1)
      K848JZ4886 (Cysteine)
    • Publication Date:
      Date Created: 20110701 Date Completed: 20111205 Latest Revision: 20131121
    • Publication Date:
      20231215
    • Accession Number:
      10.1039/c1cc11745a
    • Accession Number:
      21717004