Item request has been placed!
×
Item request cannot be made.
×
Processing Request
Effect of fluticasone furoate on interleukin 6 secretion from adenoid tissues in children with obstructive sleep apnea.
Item request has been placed!
×
Item request cannot be made.
×
Processing Request
- Author(s): Esteitie R;Esteitie R; Emani J; Sharma S; Suskind DL; Baroody FM
- Source:
Archives of otolaryngology--head & neck surgery [Arch Otolaryngol Head Neck Surg] 2011 Jun; Vol. 137 (6), pp. 576-82.
- Publication Type:
Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
- Language:
English
- Additional Information
- Source:
Publisher: American Medical Association Country of Publication: United States NLM ID: 8603209 Publication Model: Print Cited Medium: Internet ISSN: 1538-361X (Electronic) Linking ISSN: 08864470 NLM ISO Abbreviation: Arch Otolaryngol Head Neck Surg Subsets: MEDLINE
- Publication Information:
Original Publication: [Chicago, IL] : American Medical Association, [c1986-
- Subject Terms:
- Abstract:
Objective: To determine the effect of intranasal corticosteroid therapy on T-regulatory cells and other inflammatory cytokines in adenoid tissues in children with obstructive sleep apnea syndrome.
Design: Randomized, prospective, exploratory study.
Setting: Academic pediatric otolaryngology practice in a tertiary care children's hospital.
Patients: Participants included 24 children between the ages of 2 and 12 years who were undergoing adenotonsillectomy for polysomnogram-documented obstructive sleep apnea syndrome.
Intervention: Children were randomized to either no treatment (n = 13) or treatment with fluticasone furoate nasal spray, 55 μg/nostril daily (n = 11), for 2 weeks before adenotonsillectomy. Adenoid tissue was obtained at the time of the procedure.
Main Outcome Measures: The number of tissue T-regulatory cells, as determined by staining with FOXP3, CD4, and CD25, was the primary outcome measure. Staining for interleukin (IL)-10 and transforming growth factor-β protein by immunohistochemistry, and adenoid mononuclear cell spontaneous and induced release of cytokines (IL-10, IL-6, IL-12, IL-13, tumor necrosis factor, and transforming growth factor β) were secondary outcomes.
Results: Cells isolated from fluticasone furoate nasal spray-treated adenoid tissue released significantly less IL-6 spontaneously as well as upon stimulation with anti-CD3 monoclonal antibody (P = .05) compared with nontreated adenoid tissue. There were no significant differences in the number of CD4/FOXP3-, CD25/FOXP3-, or transforming growth factor β-positive cells. Intensity of staining for IL-10 was also comparable between the groups.
Conclusions: In this study, we show reduction of IL-6, a proinflammatory cytokine, in adenoid tissue obtained from children with obstructive sleep apnea syndrome treated with fluticasone furoate nasal spray. This reduction could contribute to the clinical efficacy of this class of medications in the treatment of childhood obstructive sleep apnea syndrome.
- Grant Information:
UL1 RR025014 United States RR NCRR NIH HHS
- Accession Number:
0 (Androstadienes)
0 (Glucocorticoids)
0 (Interleukins)
0 (Transforming Growth Factor beta)
0 (Tumor Necrosis Factors)
JS86977WNV (fluticasone furoate)
- Publication Date:
Date Created: 20110622 Date Completed: 20110922 Latest Revision: 20211020
- Publication Date:
20221213
- Accession Number:
10.1001/archoto.2011.86
- Accession Number:
21690510
No Comments.