[Procalcitonin-based algorithm. Management of antibiotic therapy in critically ill patients].

Prokalzitoninbasierte Algorithmen. Steuerung der Antibiotikatherapie bei kritisch kranken Patienten.

Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 0370525 Publication Model: Print Cited Medium: Internet ISSN: 1432-055X (Electronic) Linking ISSN: 00032417 NLM ISO Abbreviation: Anaesthesist Subsets: MEDLINE

Original Publication: Berlin, Springer-Verlag.

Critical Illness*; Anti-Bacterial Agents/*therapeutic use ; Biomarkers/*analysis ; Calcitonin/*analysis ; Critical Care/*methods ; Protein Precursors/*analysis ; Sepsis/*diagnosis ; Sepsis/*drug therapy; Adult ; Algorithms ; Anti-Bacterial Agents/administration & dosage ; Bacterial Infections/diagnosis ; Bacterial Infections/drug therapy ; Calcitonin Gene-Related Peptide ; Child ; Humans ; Sepsis/microbiology ; Virus Diseases/diagnosis ; Virus Diseases/drug therapy

Sepsis is one of the most cost-intensive conditions of critically ill patients in intensive care medicine. Furthermore, sepsis is known to be the leading cause of morbidity and of mortality in intensive care patients. Early initiation of antibiotic therapy can significantly reduce mortality. The development of resistance of bacterial species against antibiotics is a compelling issue to reconsider indications and administration of antibiotic treatment. Adequate indications and duration of therapy are particularly important for the use of highly potent substances in the intensive care setting. Until recently no laboratory marker has been available to distinguish bacterial infections from viral or non-infectious inflammatory responses. However, procalcitonin (PCT) appears to be the first among a large array of inflammatory markers that offers this possibility. Regular procalcitonin measurements can significantly shorten the length of antibiotic therapy, show positive influence on antibiotic costs and have no adverse affects on patient outcome.

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0 (Anti-Bacterial Agents)
0 (Biomarkers)
0 (CALCA protein, human)
0 (Protein Precursors)
9007-12-9 (Calcitonin)
JHB2QIZ69Z (Calcitonin Gene-Related Peptide)

Date Created: 20110611 Date Completed: 20111123 Latest Revision: 20211020

20231215

10.1007/s00101-011-1884-1

21660525