Antibiotic prophylaxis and early dental implant failure: a quasi-random controlled clinical trial.

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  • Additional Information
    • Source:
      Publisher: Quintessence Pub Country of Publication: England NLM ID: 101473719 Publication Model: Print Cited Medium: Print ISSN: 1756-2406 (Print) Linking ISSN: 17562406 NLM ISO Abbreviation: Eur J Oral Implantol Subsets: MEDLINE
    • Publication Information:
      Original Publication: Surrey : Quintessence Pub.
    • Subject Terms:
      Dental Implantation, Endosseous*/adverse effects ; Dental Restoration Failure*; Antibiotic Prophylaxis/*methods; Adult ; Amoxicillin/administration & dosage ; Amoxicillin-Potassium Clavulanate Combination/administration & dosage ; Analysis of Variance ; Anti-Bacterial Agents/administration & dosage ; Chi-Square Distribution ; Clavulanic Acid/administration & dosage ; Drug Combinations ; Female ; Humans ; Male ; Middle Aged ; Pain, Postoperative ; Postoperative Care ; Preoperative Care ; Surgical Wound Dehiscence ; Surgical Wound Infection
    • Abstract:
      Purpose: To compare the efficacy of three different antibiotic regimens in reducing early dental implant failure.
      Materials and Methods: In a controlled clinical trial, 270 consecutively treated patients were allocated to three antibiotic groups, alternatively, according to order of participation in the trial: Group A (2 g amoxicillin single preoperative dose), Group B (single preoperative 2 g amoxicillin followed by 500 mg three times daily for 5 days) and Group C (postoperative amoxicillin with clavulanic acid 625 mg three times daily for 5 days). Outcomes were pain, wound infection, dehiscence, adverse events possibly related to antibiotics and early implant failure. The patients were followed postoperatively at 1 week, 1 month and at the beginning of the prosthetic stage. Chi-square test and ANOVA test were used to examine differences.
      Results: In total, 240 patients were adherent to the trial protocol: Group A, 73 patients (210 implants); Group B, 79 patients (266 implants); and Group C, 88 patients (290 implants). Patients experiencing early implant failure: 12 in Group A (16.4%), 11 in Group B (13.9%) and 13 in Group C (14.8%). No statistically significant differences were observed for any of the outcome measures between the three groups.
      Conclusions: It may not be necessary to provide postoperative antibiotics in patients undergoing dental implant placement, however, these preliminary findings need to be confirmed by large multicentre clinical trials.
    • Accession Number:
      0 (Anti-Bacterial Agents)
      0 (Drug Combinations)
      23521W1S24 (Clavulanic Acid)
      74469-00-4 (Amoxicillin-Potassium Clavulanate Combination)
      804826J2HU (Amoxicillin)
    • Publication Date:
      Date Created: 20110520 Date Completed: 20110609 Latest Revision: 20210227
    • Publication Date:
      20240829
    • Accession Number:
      21594217