Nutritional and medicinal aspects of D-amino acids.

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  • Author(s): Friedman M;Friedman M; Levin CE
  • Source:
    Amino acids [Amino Acids] 2012 May; Vol. 42 (5), pp. 1553-82. Date of Electronic Publication: 2011 Apr 26.
  • Publication Type:
    Journal Article; Review
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Springer-Verlag Country of Publication: Austria NLM ID: 9200312 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1438-2199 (Electronic) Linking ISSN: 09394451 NLM ISO Abbreviation: Amino Acids Subsets: MEDLINE
    • Publication Information:
      Original Publication: Wien ; New York : Springer-Verlag, c1991-
    • Subject Terms:
      Diet* ; Isomerism*; Amino Acids/*metabolism ; Peptides/*metabolism; Amino Acids/chemistry ; Animals ; Dietary Proteins/metabolism ; Humans ; Mice ; Nutritive Value ; Peptides/chemistry
    • Abstract:
      This paper reviews and interprets a method for determining the nutritional value of D-amino acids, D-peptides, and amino acid derivatives using a growth assay in mice fed a synthetic all-amino acid diet. A large number of experiments were carried out in which a molar equivalent of the test compound replaced a nutritionally essential amino acid such as L-lysine (L-Lys), L-methionine (L-Met), L-phenylalanine (L-Phe), and L-tryptophan (L-Trp) as well as the semi-essential amino acids L-cysteine (L-Cys) and L-tyrosine (L-Tyr). The results show wide-ranging variations in the biological utilization of test substances. The method is generally applicable to the determination of the biological utilization and safety of any amino acid derivative as a potential nutritional source of the corresponding L-amino acid. Because the organism is forced to use the D-amino acid or amino acid derivative as the sole source of the essential or semi-essential amino acid being replaced, and because a free amino acid diet allows better control of composition, the use of all-amino-acid diets for such determinations may be preferable to protein-based diets. Also covered are brief summaries of the widely scattered literature on dietary and pharmacological aspects of 27 individual D-amino acids, D-peptides, and isomeric amino acid derivatives and suggested research needs in each of these areas. The described results provide a valuable record and resource for further progress on the multifaceted aspects of D-amino acids in food and biological samples.
    • Accession Number:
      0 (Amino Acids)
      0 (Dietary Proteins)
      0 (Peptides)
    • Publication Date:
      Date Created: 20110427 Date Completed: 20121001 Latest Revision: 20120424
    • Publication Date:
      20240829
    • Accession Number:
      10.1007/s00726-011-0915-1
    • Accession Number:
      21519915