New insights on the roles of BMP signaling in bone-A review of recent mouse genetic studies.

Publisher: Ios Press Country of Publication: Netherlands NLM ID: 8807441 Publication Model: Print Cited Medium: Internet ISSN: 1872-8081 (Electronic) Linking ISSN: 09516433 NLM ISO Abbreviation: Biofactors Subsets: MEDLINE

Publication: Amsterdam : Ios Press
Original Publication: Oxford ; Washington, DC : Published for the International Union of Biochemistry by IRL Press, [c1988-

Bone Morphogenetic Proteins/*metabolism ; Bone and Bones/*metabolism; Animals ; Bone Morphogenetic Proteins/genetics ; Mice ; Signal Transduction/genetics ; Signal Transduction/physiology

It is well known that Bone morphogenetic proteins (BMPs) induce bone formation and that some BMPs, including BMP2 and BMP7, are clinically used in orthopedics. Signaling by BMPs plays an important role in a variety of cell-types in bone such as osteoblasts, chondrocytes, and osteoclasts. It is recently reported using an osteoblast-targeted deletion of BMP signaling that BMP signaling in osteoblasts physiologically induces bone resorption by enhancing osteoclastogenesis via the RANKL-OPG pathway and reduces bone mass. In this review, the physiological function of BMP signaling in bone will be focused, and the current outcomes from mouse genetic studies will be discuss.
(Copyright © 2011 International Union of Biochemistry and Molecular Biology, Inc.)

J Biol Chem. 2005 Nov 11;280(45):37660-8. (PMID: 16150699)
J Biol Chem. 2005 Jul 22;280(29):26770-5. (PMID: 15908424)
Endocrinology. 2001 Aug;142(8):3656-62. (PMID: 11459815)
J Biol Chem. 2005 Jan 28;280(4):2498-502. (PMID: 15545262)
Cell. 1998 Apr 17;93(2):165-76. (PMID: 9568710)
Proc Natl Acad Sci U S A. 2003 Oct 14;100(21):12277-82. (PMID: 14523231)
J Med Genet. 2002 Feb;39(2):91-7. (PMID: 11836356)
PLoS Biol. 2004 Nov;2(11):e355. (PMID: 15492776)
Trends Genet. 2003 Aug;19(8):458-66. (PMID: 12902164)
Am J Med Genet. 2002 Jun 15;110(2):144-52. (PMID: 12116252)
Nature. 2009 Jan 22;457(7228):490-4. (PMID: 19078959)
J Orthop Res. 2010 Mar;28(3):384-9. (PMID: 19780203)
J Cell Biochem. 2005 Feb 1;94(2):403-18. (PMID: 15526274)
N Engl J Med. 2003 Dec 25;349(26):2483-94. (PMID: 14695408)
Nat Struct Mol Biol. 2004 May;11(5):481-8. (PMID: 15064755)
Development. 1996 Oct;122(10):2977-86. (PMID: 8898212)
Genes Dev. 2003 Aug 15;17(16):1963-8. (PMID: 12923052)
Genes Dev. 1995 Dec 15;9(24):3027-37. (PMID: 8543149)
Development. 2008 Nov;135(22):3801-11. (PMID: 18927151)
Dev Biol. 2010 May 1;341(1):246-54. (PMID: 20211162)
Cell. 1996 Aug 23;86(4):599-606. (PMID: 8752214)
Cell. 1997 Apr 18;89(2):309-19. (PMID: 9108485)
Am J Hum Genet. 2007 Aug;81(2):388-96. (PMID: 17668388)
Am J Hum Genet. 2001 Mar;68(3):577-89. (PMID: 11179006)
J Bone Miner Res. 2008 Jun;23(6):860-9. (PMID: 18269310)
Front Biosci. 2003 May 01;8:d855-69. (PMID: 12700086)
J Bone Miner Res. 2006 Jul;21(7):1022-33. (PMID: 16813523)
Bone. 2000 Oct;27(4):479-86. (PMID: 11033442)
PLoS Genet. 2006 Dec;2(12):e216. (PMID: 17194222)
J Bone Miner Res. 2000 Apr;15(4):663-73. (PMID: 10780858)
J Biol Chem. 1998 Oct 2;273(40):25628-36. (PMID: 9748228)
Growth Factors. 2004 Dec;22(4):233-41. (PMID: 15621726)
Cytokine Growth Factor Rev. 2005 Jun;16(3):265-78. (PMID: 15871922)
Hum Mol Genet. 2001 Mar 1;10(5):537-43. (PMID: 11181578)
Development. 2004 Apr;131(8):1825-33. (PMID: 15084466)
Hum Mol Genet. 2010 Jan 15;19(2):287-98. (PMID: 19864492)
Nature. 2003 May 15;423(6937):332-6. (PMID: 12748651)
Genes Dev. 1995 Sep 1;9(17):2105-16. (PMID: 7657163)
Dev Biol. 1999 Sep 15;213(2):314-26. (PMID: 10479450)
Hum Mol Genet. 2009 Mar 15;18(6):1110-21. (PMID: 19129173)
Nat Genet. 2006 Dec;38(12):1424-9. (PMID: 17099713)
Eur Spine J. 1999;8(6):485-90. (PMID: 10664308)
Genes Dev. 1995 Nov 15;9(22):2808-20. (PMID: 7590255)
J Bone Joint Surg Br. 2006 Jun;88(6):701-5. (PMID: 16720758)
J Bone Miner Res. 2006 Jun;21(6):934-45. (PMID: 16753024)
Genesis. 2002 Jun;33(2):77-80. (PMID: 12112875)
Development. 2009 Apr;136(7):1093-104. (PMID: 19224984)
J Bone Joint Surg Am. 2009 Mar 1;91(3):652-63. (PMID: 19255227)
Am J Hum Genet. 2009 Apr;84(4):483-92. (PMID: 19327734)
Nat Genet. 1997 Sep;17(1):18-9. (PMID: 9288091)
Nat Genet. 1996 Mar;12(3):315-7. (PMID: 8589725)
Cell. 2001 May 18;105(4):533-45. (PMID: 11371349)
Dev Cell. 2005 May;8(5):751-64. (PMID: 15866165)
J Biol Chem. 2004 Jun 25;279(26):27560-6. (PMID: 15090551)
Spine (Phila Pa 1976). 2006 May 1;31(10):E277-84. (PMID: 16648733)
Int J Biochem Cell Biol. 2008;40(1):46-62. (PMID: 17659995)
Nat Genet. 2006 May;38(5):525-7. (PMID: 16642017)
J Biol Chem. 2007 Jan 5;282(1):526-33. (PMID: 17085452)
J Bone Miner Res. 2010 Feb;25(2):200-10. (PMID: 19874086)
Dev Cell. 2001 Sep;1(3):423-34. (PMID: 11702953)
Nat Med. 2008 Dec;14(12):1363-9. (PMID: 19029982)
Cell. 1992 Jun 26;69(7):1067-70. (PMID: 1319842)
Am J Hum Genet. 2008 Feb;82(2):304-19. (PMID: 18252212)
Cell. 1996 Jun 28;85(7):947-50. (PMID: 8674122)
J Bone Miner Res. 2003 Oct;18(10):1842-53. (PMID: 14584895)
Bone. 2006 Oct;39(4):754-66. (PMID: 16730481)
Nature. 1994 Aug 4;370(6488):341-7. (PMID: 8047140)
Mol Cell Biol. 1994 Jun;14(6):3810-21. (PMID: 8196624)
Nat Genet. 2004 Oct;36(10):1117-21. (PMID: 15378062)
Biochem Biophys Res Commun. 2003 Jan 31;301(1):84-91. (PMID: 12535644)
Curr Opin Rheumatol. 2004 Jul;16(4):464-8. (PMID: 15201612)
Genes Dev. 2003 Feb 1;17(3):394-409. (PMID: 12569130)
J Bone Joint Surg Am. 2010 Feb;92(2):411-26. (PMID: 20124069)
Development. 1999 Jun;126(11):2551-61. (PMID: 10226013)
J Bone Joint Surg Br. 2007 Mar;89(3):342-5. (PMID: 17356146)
J Bone Miner Res. 2008 Dec;23(12):2007-17. (PMID: 18684091)
Biopolymers. 2000;55(5):399-406. (PMID: 11241215)
J Med Genet. 2005 Apr;42(4):314-7. (PMID: 15805157)
Science. 1965 Nov 12;150(3698):893-9. (PMID: 5319761)
J Biol Chem. 2005 Jun 3;280(22):21162-8. (PMID: 15802266)
Proc Natl Acad Sci U S A. 2005 Apr 5;102(14):5062-7. (PMID: 15781876)
J Bone Miner Res. 2002 May;17(5):898-906. (PMID: 12009021)
Genes Dev. 1995 Nov 15;9(22):2795-807. (PMID: 7590254)

R01 DE020843 United States DE NIDCR NIH HHS; Z01 ES071003 United States Intramural NIH HHS; ES071003-11 United States ES NIEHS NIH HHS; DE020843 United States DE NIDCR NIH HHS

0 (Bone Morphogenetic Proteins)

Date Created: 20110414 Date Completed: 20110830 Latest Revision: 20211020

20221213

PMC3551451

10.1002/biof.139

21488130