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The ENPP1 K121Q polymorphism is not associated with type 2 diabetes in northern Chinese.
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- Author(s): Shi X;Shi X; Wang L; Wang L; Jin F; Jin F; Sun J; Sun J; Sun L; Sun L; Tang L; Tang L; Yang Z; Yang Z
- Source:
Acta diabetologica [Acta Diabetol] 2011 Dec; Vol. 48 (4), pp. 303-310. Date of Electronic Publication: 2011 Mar 31.- Publication Type:
Journal Article; Research Support, Non-U.S. Gov't- Language:
English - Source:
- Additional Information
- Source: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 9200299 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-5233 (Electronic) Linking ISSN: 09405429 NLM ISO Abbreviation: Acta Diabetol Subsets: MEDLINE
- Publication Information: Publication: Berlin : Springer Verlag
Original Publication: Berlin : Springer International, c1991- - Subject Terms: Mutation, Missense* ; Polymorphism, Single Nucleotide*; Asian People/*genetics ; Diabetes Mellitus, Type 2/*genetics ; Phosphoric Diester Hydrolases/*genetics ; Pyrophosphatases/*genetics; Adult ; Aged ; China/epidemiology ; Diabetes Mellitus, Type 2/epidemiology ; Diabetes Mellitus, Type 2/metabolism ; Female ; Humans ; Male ; Middle Aged
- Abstract: The K121Q polymorphism of the ectoenzyme nucleotide pyrophosphate phosphodiesterase 1 (ENPP1) gene has been studied in relation to insulin resistance, type 2 diabetes, and obesity, and conflicting results were observed in various populations. The purpose of the present study was to investigate the prevalence of K121Q polymorphism of ENPP1 gene and to clarify whether this polymorphism is associated with type 2 diabetes susceptibility in northern Chinese population. We studied the association of the ENPP1 K121Q polymorphism with type 2 diabetes (T2D) in 639 unrelated patients and 885 control subjects with normal glucose tolerance of northern China. The patients were diagnosed in accordance with the guidelines of the American Diabetes Association (ADA). Genotypes were determined by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. The distribution of KK, KQ, and QQ genotypes among patients was 79.5, 19.2, and 1.3%, similar to that of the control group (79.2, 20.1, and 0.7%). After readjusting for the confounding effects of age, gender, and BMI, no significant effect of genotypes on T2D was found for any of the genetic models tested (recessive model, dominant model, or additive model). All clinical characteristics tested were similar among the different genotypes, and no significant associations were observed both in T2D patients and in controls. When subgroup analyses of T2D patients and non-diabetic controls were stratified according to BMI and waist circumference, the variant was still not associated with T2D. The results showed that the ENPP1 K121Q polymorphism is not associated with genetic susceptibility of type 2 diabetes in the northern Chinese population.
- Accession Number: EC 3.1.4.- (Phosphoric Diester Hydrolases)
EC 3.1.4.1 (ectonucleotide pyrophosphatase phosphodiesterase 1)
EC 3.6.1.- (Pyrophosphatases) - Publication Date: Date Created: 20110401 Date Completed: 20120325 Latest Revision: 20221207
- Publication Date: 20231215
- Accession Number: 10.1007/s00592-011-0281-1
- Accession Number: 21452007
- Source:
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