[Recent data on the group of melanotropic and lipotropic pituitary hormones (MSH-LPH) and on the brain morphinomimetic peptides (endorphins)].

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  • Author(s): Bertagna X; Girard F
  • Source:
    Annales d'endocrinologie [Ann Endocrinol (Paris)] 1978; Vol. 39 (3), pp. 201-13.
  • Publication Type:
    English Abstract; Journal Article; Review
  • Language:
    French
  • Additional Information
    • Transliterated Title:
      Données récentes sur le groupe des hormones hypophysaires mélanotropes et lipotropes (MSH-LPH) et sur les peptides cérébraux morphinomimétiques (endorphines).
    • Source:
      Publisher: Elsevier Country of Publication: France NLM ID: 0116744 Publication Model: Print Cited Medium: Print ISSN: 0003-4266 (Print) Linking ISSN: 00034266 NLM ISO Abbreviation: Ann Endocrinol (Paris) Subsets: MEDLINE
    • Publication Information:
      Publication: <1990- >: Paris : Elsevier
      Original Publication: Paris, Masson.
    • Subject Terms:
      Endorphins/*physiology ; Melanocyte-Stimulating Hormones/*physiology ; beta-Lipotropin/*physiology; Adrenocorticotropic Hormone/biosynthesis ; Animals ; Endorphins/biosynthesis ; Endorphins/pharmacology ; Humans ; Kidney Failure, Chronic/metabolism ; Nelson Syndrome/metabolism ; Protein Precursors ; Renal Dialysis ; beta-Lipotropin/biosynthesis
    • Abstract:
      It was admitted that human beta-MSH was responsible for the hyper-pigmentation observed in some syndromes associated with ACTH hypersecretion. beta-LPH was a pituitary polypeptide, containing the entire sequence of beta-MSH in its fragment 37-58, and the physiological role of which remained unknown. alpha-MSH and CLIP (Corticotrophin-like Intermediary Peptide) were thought to be specific of certain species possessing a distinct pituitary pars intermedia. Recent data give new insight upon some of these conceptions. beta-MSH seems not to exist in man; it is almost established now that plasma "Immunoreactive beta-MSH" (IR-beta-MSH) is in fact beta- and/or gamma-LPH. In chronic renal failure plasma IR-beta-MSH is elevated because of a decreased plasma disappearance rate, whereas ACTH is normal. Good evidence suggests that both LPH and ACTH are synthesized in the same pituitary cell within a common polypeptidic precursor. Endogenous peptides with morphinomimetic activity (Endorphins) have been isolated from brain and hypophysis; they are all made up of different fractions of beta-LPH-C-terminal fragment 61-91; It is likely that they represent a new class of brain neurotransmitters involved in some functions of the central nervous system, structural similarities suggest that beta-LPH may be the biosynthetic precursor of Endorphins, however such a hypothesis remains to be clearly demonstrated.
    • Number of References:
      84
    • Accession Number:
      0 (Endorphins)
      0 (Protein Precursors)
      9002-60-2 (Adrenocorticotropic Hormone)
      9002-79-3 (Melanocyte-Stimulating Hormones)
      9035-55-6 (beta-Lipotropin)
    • Publication Date:
      Date Created: 19780101 Date Completed: 19790126 Latest Revision: 20161031
    • Publication Date:
      20221208
    • Accession Number:
      214012