Erosive pustular dermatosis of the leg: long-term control with topical tacrolimus.

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  • Author(s): Dall'Olio E;Dall'Olio E; Rosina P; Girolomoni G
  • Source:
    The Australasian journal of dermatology [Australas J Dermatol] 2011 Feb; Vol. 52 (1), pp. e15-7.
  • Publication Type:
    Case Reports; Journal Article
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Wiley-Blackwell Country of Publication: Australia NLM ID: 0135232 Publication Model: Print Cited Medium: Internet ISSN: 1440-0960 (Electronic) Linking ISSN: 00048380 NLM ISO Abbreviation: Australas J Dermatol Subsets: MEDLINE
    • Publication Information:
      Publication: New South Wales : Wiley-Blackwell
      Original Publication: [Sydney] Australasian College of Dermatologists.
    • Subject Terms:
      Immunosuppressive Agents/*administration & dosage ; Leg Dermatoses/*drug therapy ; Leg Dermatoses/*pathology ; Tacrolimus/*administration & dosage; Female ; Humans ; Middle Aged ; Treatment Outcome
    • Abstract:
      Erosive pustular dermatosis of the leg is an unusual form of sterile pustulosis that typically affects the lower limbs of elderly patients. We report the cases of two women who developed erythematous skin plaques with pustules that coalesced and evolved into erosions and crusted areas. Histology showed epidermal spongiosis with subcorneal pustules and a dermal infiltrate with eosinophils and neutrophils. Lesions were treated with topical clobetasol propionate 0.05% for 10 days followed by topical tacrolimus daily until complete resolution, and then twice weekly for 1 year, without relapse. The response to topical corticosteroids and tacrolimus further support the close relationship with erosive pustular dermatosis of the scalp. Topical therapy with tacrolimus may offer good long-term disease control.
      (© 2009 The Authors. Australasian Journal of Dermatology © 2009 The Australasian College of Dermatologists.)
    • Accession Number:
      0 (Immunosuppressive Agents)
      WM0HAQ4WNM (Tacrolimus)
    • Publication Date:
      Date Created: 20110222 Date Completed: 20110705 Latest Revision: 20131121
    • Publication Date:
      20240829
    • Accession Number:
      10.1111/j.1440-0960.2009.00584.x
    • Accession Number:
      21332681