High brain lactate is not caused by a shift in the lactate dehydrogenase A/B ratio.

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  • Author(s): Quistorff B; Grunnet N
  • Source:
    Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2011 Feb 15; Vol. 108 (7), pp. E21; author reply E22. Date of Electronic Publication: 2011 Jan 28.
  • Publication Type:
    Comment; Letter
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE
    • Publication Information:
      Original Publication: Washington, DC : National Academy of Sciences
    • Subject Terms:
      Aging/*metabolism ; Biomarkers/*metabolism ; Brain/*enzymology ; L-Lactate Dehydrogenase/*metabolism ; Lactic Acid/*metabolism; Animals ; Cytosol/metabolism ; Isoenzymes/genetics ; Isoenzymes/metabolism ; Kinetics ; L-Lactate Dehydrogenase/genetics ; Mice ; Oxidation-Reduction ; Pyruvic Acid/metabolism
    • Comments:
      Comment on: Proc Natl Acad Sci U S A. 2010 Nov 16;107(46):20087-92. (PMID: 21041631)
    • References:
      J Cell Biochem. 2003 May 1;89(1):67-79. (PMID: 12682909)
      J Theor Biol. 2006 Jun 7;240(3):464-74. (PMID: 16325864)
      J Appl Physiol (1985). 2009 Nov;107(5):1674-5. (PMID: 19899215)
      Proc Natl Acad Sci U S A. 2010 Nov 16;107(46):20087-92. (PMID: 21041631)
    • Accession Number:
      0 (Biomarkers)
      0 (Isoenzymes)
      33X04XA5AT (Lactic Acid)
      8558G7RUTR (Pyruvic Acid)
      EC 1.1.1.27 (L-Lactate Dehydrogenase)
    • Publication Date:
      Date Created: 20110201 Date Completed: 20110414 Latest Revision: 20211020
    • Publication Date:
      20221213
    • Accession Number:
      PMC3041136
    • Accession Number:
      10.1073/pnas.1017750108
    • Accession Number:
      21278331