Melanin synthesis inhibitors from Balanophora fungosa.

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  • Author(s): Ogi T;Ogi T; Higa M; Maruyama S
  • Source:
    Journal of agricultural and food chemistry [J Agric Food Chem] 2011 Feb 23; Vol. 59 (4), pp. 1109-14. Date of Electronic Publication: 2011 Jan 25.
  • Publication Type:
    Journal Article
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: American Chemical Society Country of Publication: United States NLM ID: 0374755 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-5118 (Electronic) Linking ISSN: 00218561 NLM ISO Abbreviation: J Agric Food Chem Subsets: MEDLINE
    • Publication Information:
      Original Publication: Washington, American Chemical Society.
    • Subject Terms:
      Balanophoraceae/*chemistry ; Melanins/*antagonists & inhibitors ; Melanins/*biosynthesis ; Plant Extracts/*pharmacology; Cell Line, Tumor ; Enzyme Inhibitors/pharmacology ; Humans ; Melanocytes/metabolism ; Melanoma ; Models, Biological ; Monophenol Monooxygenase/antagonists & inhibitors ; Plant Extracts/chemistry ; Skin ; Trypsin Inhibitors/pharmacology ; Tryptases/antagonists & inhibitors
    • Abstract:
      Tyrosinase, trypsin, and tryptase are known to play important roles in melanin production of human skin. This paper describes the study of the inhibitory effect of Balanophora fungosa on melanin. The 50% EtOH extract obtained from B. fungosa indicated an inhibitory effect on mushroom tyrosinase activity with an IC(50) value of 15 μg/mL. Bioassay-guided fractionation of the active extract resulted in the isolation of four known compounds. Their structures were identified as 1-O-(E)-caffeoyl-3-O-galloyl-4,6-(S)-HHDP-β-d-glucopyranose (1), 1-O-(E)-caffeoyl-3,4,6-tri-O-galloyl-β-d-glucopyranose (2), caffeoyl-β-d-glucopyranose (3), and abietin (4) on the basis of spectroscopic analyses and comparison of their spectral data with those in the literature. Compounds 1 and 2 prevented pigmentation of melanin in a three-dimensional cultured human skin model. Furthermore, compounds 1 and 2 indicated inhibitory activities against trypsin and tryptase.
    • Accession Number:
      0 (Enzyme Inhibitors)
      0 (Melanins)
      0 (Plant Extracts)
      0 (Trypsin Inhibitors)
      EC 1.14.18.1 (Monophenol Monooxygenase)
      EC 3.4.21.59 (Tryptases)
    • Publication Date:
      Date Created: 20110127 Date Completed: 20110502 Latest Revision: 20110216
    • Publication Date:
      20221213
    • Accession Number:
      10.1021/jf1035542
    • Accession Number:
      21265535