Emerging therapies for atherosclerosis prevention and management.

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  • Author(s): Chyu KY;Chyu KY; Shah PK
  • Source:
    Cardiology clinics [Cardiol Clin] 2011 Feb; Vol. 29 (1), pp. 123-35. Date of Electronic Publication: 2010 Dec 17.
  • Publication Type:
    Journal Article; Review
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Elsevier Country of Publication: Netherlands NLM ID: 8300331 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1558-2264 (Electronic) Linking ISSN: 07338651 NLM ISO Abbreviation: Cardiol Clin Subsets: MEDLINE
    • Publication Information:
      Publication: 2005- : Amsterdam : Elsevier
      Original Publication: Philadelphia : Saunders, c1983-
    • Subject Terms:
      Atherosclerosis/*prevention & control ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/*therapeutic use ; Hypolipidemic Agents/*therapeutic use ; Lipids/*blood; Atherosclerosis/blood ; Humans ; Risk Factors
    • Abstract:
      Atherosclerosis is a chronic immunoinflammatory disease involving medium and large arteries, resulting from a complex interaction between genetic and environmental risk factors. Acute atherosclerotic vascular disease largely results from thrombosis that supervenes on a disrupted atherosclerotic plaque. A healthy lifestyle coupled with management of modifiable risk factors reduces the adverse clinical consequences of atherothrombosis. Reducing low-density lipoprotein cholesterol levels using statins and other agents is the primary pharmacologic approach to stabilize atherosclerosis, but a large residual risk burden remains, stimulating the search for additional therapies for atherosclerosis management. This review focuses on new and emerging therapeutic strategies targeting atherosclerosis.
      (Copyright © 2011 Elsevier Inc. All rights reserved.)
    • Accession Number:
      0 (Hydroxymethylglutaryl-CoA Reductase Inhibitors)
      0 (Hypolipidemic Agents)
      0 (Lipids)
    • Publication Date:
      Date Created: 20110125 Date Completed: 20110517 Latest Revision: 20110124
    • Publication Date:
      20221213
    • Accession Number:
      10.1016/j.ccl.2010.10.003
    • Accession Number:
      21257104