Uncontrolled home blood pressure in the morning is associated with nephropathy in Japanese type 2 diabetes.

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  • Additional Information
    • Source:
      Publisher: Springer Verlag Country of Publication: Japan NLM ID: 8511258 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1615-2573 (Electronic) Linking ISSN: 09108327 NLM ISO Abbreviation: Heart Vessels Subsets: MEDLINE
    • Publication Information:
      Publication: Tokyo : Springer Verlag
      Original Publication: Tokyo ; Secaucus, NY : Springer International, c1985-
    • Subject Terms:
      Blood Pressure*/drug effects ; Circadian Rhythm*; Diabetes Mellitus, Type 2/*epidemiology ; Diabetic Nephropathies/*epidemiology ; Hypertension/*epidemiology; Aged ; Analysis of Variance ; Antihypertensive Agents/therapeutic use ; Blood Pressure Determination ; Chi-Square Distribution ; Diabetes Mellitus, Type 2/physiopathology ; Diabetic Nephropathies/physiopathology ; Diabetic Nephropathies/prevention & control ; Female ; Humans ; Hypertension/diagnosis ; Hypertension/drug therapy ; Hypertension/physiopathology ; Japan/epidemiology ; Logistic Models ; Male ; Middle Aged ; Predictive Value of Tests ; Prevalence ; Risk Assessment ; Risk Factors ; Time Factors ; White Coat Hypertension/epidemiology ; White Coat Hypertension/physiopathology
    • Abstract:
      The purposes of this study were to investigate the state of blood pressure control level and to investigate the relationship between blood pressure control level and nephropathy in Japanese type 2 diabetes. We measured clinic and home blood pressure in 923 type 2 diabetic patients. According to the criteria for hypertension in the Japanese Society of Hypertension Guidelines 2009, patients were classified into four groups by clinic systolic blood pressure (130 mmHg) and morning systolic blood pressure (125 mmHg), as follows: controlled hypertension (CH), white-coat hypertension (WCH), masked hypertension (MH), and sustained hypertension (SH). Of all patients, 13.9, 12.6, 13.3, and 60.2% were identified as having CH, WCH, MH, and SH, respectively. The average number of drugs prescribed was 1.8. We assessed the association between blood pressure control level and nephropathy in diabetic patients. The degree of urinary albumin excretion and the prevalence of nephropathy in diabetic patients were higher in MH and SH groups than those in the CH group. The majority of patients had poor blood pressure control, regardless of ongoing conventional antihypertensive therapy, and diabetic patients with MH and SH were associated with nephropathy. It is suggested that more aggressive antihypertensive treatment is recommended to prevent nephropathy in diabetic patients.
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    • Accession Number:
      0 (Antihypertensive Agents)
    • Publication Date:
      Date Created: 20110112 Date Completed: 20120312 Latest Revision: 20211020
    • Publication Date:
      20231215
    • Accession Number:
      10.1007/s00380-010-0107-z
    • Accession Number:
      21221599