Kisspeptins and the neuroendocrine control of reproduction.

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  • Author(s): Navarro VM;Navarro VM; Tena-Sempere M
  • Source:
    Frontiers in bioscience (Scholar edition) [Front Biosci (Schol Ed)] 2011 Jan 01; Vol. 3 (1), pp. 267-75. Date of Electronic Publication: 2011 Jan 01.
  • Publication Type:
    Journal Article; Research Support, Non-U.S. Gov't; Review
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: IMR Press Country of Publication: Singapore NLM ID: 101485241 Publication Model: Electronic Cited Medium: Internet ISSN: 1945-0524 (Electronic) Linking ISSN: 19450516 NLM ISO Abbreviation: Front Biosci (Schol Ed) Subsets: MEDLINE
    • Publication Information:
      Publication: 2022- : Singapore : IMR Press
      Original Publication: Searington, NY : Frontiers in bioscience
    • Subject Terms:
      Arcuate Nucleus of Hypothalamus/*metabolism ; Gonadal Steroid Hormones/*metabolism ; Gonadotropin-Releasing Hormone/*metabolism ; Neurosecretory Systems/*physiology ; Neurotransmitter Agents/*metabolism ; Reproduction/*physiology ; Tumor Suppressor Proteins/*physiology; Animals ; Dynorphins/metabolism ; Humans ; Kisspeptins ; Neurokinin B/metabolism ; Tumor Suppressor Proteins/metabolism
    • Abstract:
      Reproductive function, as essential for the survival of species, is under the control of a vast array of regulatory factors that ultimately modulate the release of GnRH. However, GnRH neurons lack the ability to directly sense most of these signals; hence, intermediate pathways are required. Kisspeptins have recently emerged as a pivotal piece in the reproductive brain, serving primarily as conduits for central and peripheral regulatory cues of GnRH release. Different populations of hypothalamic Kiss1 neurons have been described, which mediate either the positive or negative feedback of sex steroids in the sexually differentiated brain of rodents. Kisspeptins, however, are not the only recently-appointed contributors to this integrative process. Indeed, neurokinin B (NKB) and dynorphin have been described to co-localize within Kiss1 neurons at the arcuate nucleus in different species, and may contribute to the regulation of kisspeptin release. In this work, we provide a concise overview of the major reproductive headlines of kisspeptins, focusing on their role as mediators of sex steroid feedback and their interaction with key neurotransmitters, such as NKB and dynorphin.
    • Accession Number:
      0 (Gonadal Steroid Hormones)
      0 (KISS1 protein, human)
      0 (Kisspeptins)
      0 (Neurotransmitter Agents)
      0 (Tumor Suppressor Proteins)
      33515-09-2 (Gonadotropin-Releasing Hormone)
      74913-18-1 (Dynorphins)
      86933-75-7 (Neurokinin B)
    • Publication Date:
      Date Created: 20110104 Date Completed: 20110517 Latest Revision: 20220227
    • Publication Date:
      20221213
    • Accession Number:
      10.2741/s150
    • Accession Number:
      21196375