[Influence of metabolism modifiers of cyclic nucleotides on contractility of right ventricle of rat heart with intact and removed endocardial endothelium].

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  • Additional Information
    • Source:
      Publisher: Srpski Lekarski Drustvo Country of Publication: Serbia NLM ID: 0027440 Publication Model: Print Cited Medium: Print ISSN: 0370-8179 (Print) Linking ISSN: 03708179 NLM ISO Abbreviation: Srp Arh Celok Lek Subsets: MEDLINE
    • Publication Information:
      Publication: Beograd : Srpski Lekarski Drustvo
      Original Publication: Belgrade.
    • Subject Terms:
      Endocardium/*physiology ; Endothelium/*physiology ; Imidazoles/*pharmacology ; Myocardial Contraction/*physiology ; Nucleotides, Cyclic/*metabolism ; Phosphodiesterase Inhibitors/*pharmacology ; Theophylline/*pharmacology ; Ventricular Function, Right/*drug effects; Animals ; Endocardium/drug effects ; Endothelium/drug effects ; Enzyme Activation ; In Vitro Techniques ; Myocardial Contraction/drug effects ; Phosphoric Diester Hydrolases/metabolism ; Rats ; Rats, Wistar ; Ventricular Function, Right/physiology
    • Abstract:
      Introduction: Endocardial endothelium, a natural biological barrier between circulating blood in heart ventricle and cells, creates a complex yet finely tuned balance of interactions with the immediate environment.
      Objective: We investigated the roles of theophylline, nonspecific phosphodiesterase inhibitor, and imidazole, an activator of phosphodiesterase on contractility of the right ventricle of rat heart, with intact and removed endocardial endothelium.
      Methods: Adult rats, of both sexes, type Wistar albino, were used in this experiment. All experiments were conducted on the preparations of the right ventricle using two experimental models. In the first experimental model, an endocardial endothelium (EE) was preserved, and in the second model, an endocardial endothelium (-EE) was removed using 1% solution Triton X-100.
      Results: Theophylline (1 x 10(-2) mol/l) expressed the positive inotropic effect on the heart, regardless of the presence of the endocardial endothelium. Inotropic response as multiple process can be induced by inhibition of phosphodiesterase, accumulation of cyclic nucleotides and activation of Ca2+ channels. Imidazole (2 x 10(-3) mol/l) increased the contractility of the right ventricle of the heart with EE. The modulator effect of endocardial endothelium on contractility of imidazole proved to be significant. As imidazole influenced the contractility of the right ventricle only in the presence of the endocardial endothelium, it is assumed that its effect is mediated via deliverance of endothelial mediators with positive inotropic effect.
      Conclusion: An intact endocardial endothelium is necessary for completion of contractile performance of the heart.
    • Accession Number:
      0 (Imidazoles)
      0 (Nucleotides, Cyclic)
      0 (Phosphodiesterase Inhibitors)
      7GBN705NH1 (imidazole)
      C137DTR5RG (Theophylline)
      EC 3.1.4.- (Phosphoric Diester Hydrolases)
    • Publication Date:
      Date Created: 20101225 Date Completed: 20110120 Latest Revision: 20190918
    • Publication Date:
      20231215
    • Accession Number:
      10.2298/sarh1010577s
    • Accession Number:
      21180087