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Effect of preparation techniques on the properties of curcumin liposomes: characterization of size, release and cytotoxicity on a squamous oral carcinoma cell line.
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- Author(s): Gosangari SL;Gosangari SL; Watkin KL
- Source:
Pharmaceutical development and technology [Pharm Dev Technol] 2012 Jan-Feb; Vol. 17 (1), pp. 103-9. Date of Electronic Publication: 2010 Nov 24.- Publication Type:
Journal Article- Language:
English - Source:
- Additional Information
- Source: Publisher: Informa Healthcare Country of Publication: England NLM ID: 9610932 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-9867 (Electronic) Linking ISSN: 10837450 NLM ISO Abbreviation: Pharm Dev Technol Subsets: MEDLINE
- Publication Information: Publication: London : Informa Healthcare
Original Publication: Monticello, NY : Marcel Dekker, c1996- - Subject Terms: Antineoplastic Agents, Phytogenic/*administration & dosage ; Antineoplastic Agents, Phytogenic/*pharmacology ; Carcinoma, Squamous Cell/*drug therapy ; Curcumin/*administration & dosage ; Curcumin/*pharmacology ; Mouth Neoplasms/*drug therapy; Antineoplastic Agents, Phytogenic/chemistry ; Carcinoma, Squamous Cell/pathology ; Cell Line, Tumor ; Chemistry, Pharmaceutical ; Cholesterol ; Curcumin/chemistry ; Drug Compounding ; Drug Stability ; Drug Storage ; Excipients ; Humans ; Light ; Liposomes ; Microscopy, Confocal ; Microscopy, Electron, Transmission ; Mouth Neoplasms/pathology ; Particle Size ; Scattering, Radiation ; Solubility
- Abstract: Curcumin, a chemopreventive agent, was incorporated into liposomes using different preparation techniques and characterized for parameters such as drug loading efficiency, size, in vitro release and in vitro cytotoxicity on a squamous carcinoma cell line. Liposomes were prepared with different methods - thin layer evaporation, ethanol injection and sonication methods, respectively, obtaining, multilamellar vesicles (MLVs) and small unilamellar vesicles (SUVs). The preparation techniques influenced the size, encapsulation efficiency, in vitro release and cytotoxicity profiles. Encapsulation efficiency increased with decrease in drug to lipid ratio in the following rank order - MLVs > SUVs > ethanol injection vesicles. In vitro release and in vitro cytotoxicity were a function of the size of vesicle, which varied depending on the preparation technique. Based on these results, it can be concluded that different liposomal formulations can be employed to achieve unique in vivo needs in cancer chemotherapy.
- Accession Number: 0 (Antineoplastic Agents, Phytogenic)
0 (Excipients)
0 (Liposomes)
97C5T2UQ7J (Cholesterol)
IT942ZTH98 (Curcumin) - Publication Date: Date Created: 20101125 Date Completed: 20120410 Latest Revision: 20131121
- Publication Date: 20231215
- Accession Number: 10.3109/10837450.2010.522583
- Accession Number: 21091385
- Source:
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