Inhibition effects of the classical pathway complement of three Sorghum bicolor from South Korea.

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  • Author(s): Chung IM;Chung IM; Kim MJ; Park DS; Moon HI
  • Source:
    Immunopharmacology and immunotoxicology [Immunopharmacol Immunotoxicol] 2011 Sep; Vol. 33 (3), pp. 447-9. Date of Electronic Publication: 2010 Nov 16.
  • Publication Type:
    Journal Article; Research Support, Non-U.S. Gov't; Retracted Publication
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Informa Healthcare Country of Publication: England NLM ID: 8800150 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-2513 (Electronic) Linking ISSN: 08923973 NLM ISO Abbreviation: Immunopharmacol Immunotoxicol Subsets: MEDLINE
    • Publication Information:
      Publication: London : Informa Healthcare
      Original Publication: New York, N.Y. : Marcel Dekker, c1987-
    • Subject Terms:
      Complement Pathway, Classical/*drug effects ; Plant Extracts/*pharmacology ; Sorghum/*chemistry; Animals ; Cells, Cultured ; Erythrocytes/drug effects ; Humans ; Inhibitory Concentration 50 ; Rabbits ; Republic of Korea ; Sheep
    • Abstract:
      The present study evaluated the anti-complement effects from organic solvent extracts of three varieties (Hwanggeumchal Sorghum, Chal Sorghum, and Heuin Sorghum) from Sorghum bicolor in classical pathway complement system. We have evaluated organic solvent extract from Sorghum bicolor varieties with regard to its anti-complement activity. Chal Sorghum ethyl acetate extract showed inhibitory activity against complement system with 50% inhibitory concentrations (IC(50)) values of 38.7 μg/mL. This is the first report of anti-complement activity from Sorghum bicolor varieties.
    • Comments:
      Retraction in: Immunopharmacol Immunotoxicol. 2012 Dec;34(6):1077-8. doi: 10.3109/08923973.2012.710052. (PMID: 22928946)
    • Accession Number:
      0 (Plant Extracts)
    • Publication Date:
      Date Created: 20101117 Date Completed: 20120119 Latest Revision: 20121228
    • Publication Date:
      20250114
    • Accession Number:
      10.3109/08923973.2010.532804
    • Accession Number:
      21077803