The impact of bisphenol A and triclosan on immune parameters in the U.S. population, NHANES 2003-2006.

Publisher: National Institute of Environmental Health Sciences Country of Publication: United States NLM ID: 0330411 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1552-9924 (Electronic) Linking ISSN: 00916765 NLM ISO Abbreviation: Environ Health Perspect Subsets: MEDLINE

Original Publication: Research Triangle Park, N. C. National Institute of Environmental Health Sciences.

Endocrine Disruptors/*toxicity ; Immune System/*drug effects ; Phenols/*toxicity ; Triclosan/*toxicity; Adult ; Antibodies, Viral/blood ; Benzhydryl Compounds ; Biomarkers/blood ; Biomarkers/metabolism ; Biomarkers/urine ; Child ; Cytomegalovirus/immunology ; Endocrine Disruptors/metabolism ; Female ; Humans ; Immune System/metabolism ; Immunoglobulin G/blood ; Linear Models ; Male ; Nutrition Surveys ; Phenols/metabolism ; Phenols/urine ; Triclosan/metabolism ; Triclosan/urine ; United States

Background: Exposure to environmental toxicants is associated with numerous disease outcomes, many of which involve underlying immune and inflammatory dysfunction.
Objectives: To address the gap between environmental exposures and immune dysfunction, we investigated the association of two endocrine-disrupting compounds (EDCs) with markers of immune function.
Methods: Using data from the 2003-2006 National Health and Nutrition Examination Survey, we compared urinary bisphenol A (BPA) and triclosan levels with serum cytomegalovirus (CMV) antibody levels and diagnosis of allergies or hay fever in U.S. adults and children ≥ 6 years of age. We used multivariate ordinary least squares linear regression models to examine the association of BPA and triclosan with CMV antibody titers, and multivariate logistic regression models to investigate the association of these chemicals with allergy or hay fever diagnosis. Statistical models were stratified by age (< 18 years and ≥ 18 years).
Results: In analyses adjusted for age, sex, race, body mass index, creatinine levels, family income, and educational attainment, in the ≥ 18-year age group, higher urinary BPA levels were associated with higher CMV antibody titers (p < 0.001). In the < 18-year age group, lower levels of BPA were associated with higher CMV antibody titers (p < 0.05). However, triclosan, but not BPA, showed a positive association with allergy or hay fever diagnosis. In the < 18-year age group, higher levels of triclosan were associated with greater odds of having been diagnosed with allergies or hay fever (p < 0.01).
Conclusions: EDCs such as BPA and triclosan may negatively affect human immune function as measured by CMV antibody levels and allergy or hay fever diagnosis, respectively, with differential consequences based on age. Additional studies should be done to investigate these findings.

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R21 NR011181 United States NR NINR NIH HHS; R21 NR011181-02 United States NR NINR NIH HHS; 1R21NR011181-01 United States NR NINR NIH HHS

0 (Antibodies, Viral)
0 (Benzhydryl Compounds)
0 (Biomarkers)
0 (Endocrine Disruptors)
0 (Immunoglobulin G)
0 (Phenols)
4NM5039Y5X (Triclosan)
MLT3645I99 (bisphenol A)

Date Created: 20101111 Date Completed: 20110613 Latest Revision: 20211020

20240829

PMC3060004

10.1289/ehp.1002883

21062687