[Chronopharmacodynamics of delayed-action cardiac glycosides and nitrates].

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
Read More Add to Saved list
  • Author(s): Zaslavskaia RM; Vilkovyskiĭ FA; Goncharov LF
  • Source:
    Kardiologiia [Kardiologiia] 1990 Dec; Vol. 30 (12), pp. 11-3.
  • Publication Type:
    Clinical Trial; Comparative Study; Controlled Clinical Trial; English Abstract; Journal Article
  • Language:
    Russian
  • Additional Information
    • Transliterated Title:
      Khronofarmakodinamika serdechnykh glikozidov i nitratov prolongi- rovannogo deĭstviia.
    • Source:
      Publisher: OOO Obshchestvo spet︠s︡ialistov po serdechnoĭ nedostatochnosti Country of Publication: Russia (Federation) NLM ID: 0376351 Publication Model: Print Cited Medium: Print ISSN: 0022-9040 (Print) Linking ISSN: 00229040 NLM ISO Abbreviation: Kardiologiia Subsets: MEDLINE
    • Publication Information:
      Publication: <2017->: Moskva : OOO Obshchestvo spet︠s︡ialistov po serdechnoĭ nedostatochnosti
      Original Publication: Moskva.
    • Subject Terms:
      Cardiomyopathy, Dilated/*drug therapy ; Coronary Disease/*drug therapy ; Hemodynamics/*drug effects ; Isosorbide Dinitrate/*administration & dosage ; Strophanthins/*administration & dosage; Aged ; Cardiomyopathy, Dilated/physiopathology ; Circadian Rhythm ; Coronary Disease/physiopathology ; Delayed-Action Preparations ; Hemodynamics/physiology ; Humans ; Isosorbide Dinitrate/pharmacology ; Middle Aged ; Strophanthins/pharmacokinetics
    • Abstract:
      In 96 patients with coronary heart disease and stage II circulatory failure, the chronopharmacodynamics of strophanthin, corglycon, and nitrosorbide was studied by using acute clinical and pharmacological tests in the morning (8.00 a.m.), in the afternoon (2.00 p.m.), and in the evening (8.00 p.m.). Central and peripheral hemodynamic parameters were measured prior to and following 5, 15, 30, 60, and 120 min of intravenous injection of cardiac glycosides or sublingual administration of nitrosorbide in a dose of 10 mg for 240 min. The investigations showed that there were the most profound hemodynamic changes in the morning if strophanthin was used and in the afternoon if corglycon was given. The maximal reduction in heart pre- and afterload was seen in the morning when nitrosorbide was applied, the most improvement in central hemodynamic parameters was observed in the evening when nitrosorbide was used.
    • Accession Number:
      0 (Delayed-Action Preparations)
      0 (Strophanthins)
      IA7306519N (Isosorbide Dinitrate)
      JY264VIR1Y (convallatoxin)
    • Publication Date:
      Date Created: 19901201 Date Completed: 19910722 Latest Revision: 20170310
    • Publication Date:
      20221208
    • Accession Number:
      2097386