The Survival of B. Subtilis Spores in Dicalcium Phosphate, Lactose, and Corn Starch And Their Binary Mixtures During Tableting.

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    • Abstract:
      The article presents information on a study which examined microbial contamination in the initial stages of tablet manufacture. For the purpose of this study, three materials-dicalcium phosphate, lactose, and corn starch, and their binary mixtures were contaminated with B. subtilis spores and used to prepare tablets. The mechanism of microbial kill during tablet compression was investigated by using the compression characteristics of the materials. The process included compression at four compression speeds on a single-punch tableting machine and at a much slower speed on a hydraulic hand press.