[Evaluation of the effect of bimatoprost/timolol fixed combination on ocular blood flow in patients with ocular hypertension using colour Doppler imaging. Preliminary study].

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  • Additional Information
    • Transliterated Title:
      Evaluación mediante ecografía doppler color del efecto de la combinación fija bimatoprost/timolol sobre el flujo sanguíneo ocular en pacientes con hipertensión ocular. Estudio preliminar.
    • Source:
      Publisher: Elsevier Doyma Country of Publication: Spain NLM ID: 1304603 Publication Model: Print Cited Medium: Internet ISSN: 1989-7286 (Electronic) Linking ISSN: 03656691 NLM ISO Abbreviation: Arch Soc Esp Oftalmol Subsets: MEDLINE
    • Publication Information:
      Publication: Jan. 2010- : Madrid : Elsevier Doyma
      Original Publication: -Dec. 2009 : Madrid : Sociedad Española de Oftalmología
    • Subject Terms:
      Ultrasonography, Doppler, Color*; Amides/*administration & dosage ; Antihypertensive Agents/*administration & dosage ; Cloprostenol/*analogs & derivatives ; Eye/*blood supply ; Eye/*diagnostic imaging ; Ocular Hypertension/*diagnostic imaging ; Ocular Hypertension/*physiopathology ; Regional Blood Flow/*drug effects ; Timolol/*administration & dosage; Amides/therapeutic use ; Antihypertensive Agents/therapeutic use ; Bimatoprost ; Cloprostenol/administration & dosage ; Cloprostenol/therapeutic use ; Double-Blind Method ; Drug Combinations ; Female ; Humans ; Male ; Middle Aged ; Ocular Hypertension/drug therapy ; Prospective Studies ; Timolol/therapeutic use
    • Abstract:
      Purpose: To investigate the effects of topical bimatoprost (0.3 mg/ml)/timolol maleate (5 mg/ ml) fixed combination on retrobulbar blood flow in patients with ocular hypertension (OHT).
      Patients and Methods: Twenty consecutive patients with OHT were prospectively randomised to either bimatoprost/timolol or placebo during a 12 weeks double masked treatment trial. Examinations were performed at baseline and after 12 weeks of treatment. Visual acuity, intraocular pressure (IOP), slit-lamp examination, automated static perimetry, systemic blood pressure and heart rate were all recorded. Retrobulbar blood flow measurements of the ophthalmic artery (AO) and central retinal artery (CRA) were measured by colour Doppler imaging.
      Results: IOP was significantly decreased by bimatoprost/timolol fixed combination (p < 0.0001). Bimatoprost/timolol fixed combination therapy resulted in a significant increase in end diastolic velocity (EDV) of the CRA (p = 0.03). In patients treated with bimatoprost/timolol a statistically significant correlation between IOP and EDV was observed after 12 weeks of treatment (r = -0.511, p = 0.045). The systolic (p = 0.54) and diastolic (p = 0.67) blood pressures and heart rate (p = 0.10) did not show statistically significant differences during the study period.
      Conclusions: Topical bimatoprost/timolol fixed combination significantly reduced IOP in patients with OHT. However, the only significant change observed in retrobulbar haemodynamics was an increase in EDV of the CRA, probably associated with a reduction in IOP.
    • Accession Number:
      0 (Amides)
      0 (Antihypertensive Agents)
      0 (Drug Combinations)
      4208238832 (Cloprostenol)
      817W3C6175 (Timolol)
      QXS94885MZ (Bimatoprost)
    • Publication Date:
      Date Created: 20100923 Date Completed: 20110228 Latest Revision: 20161125
    • Publication Date:
      20221213
    • Accession Number:
      20858400