Xanthine oxidase inhibitory properties of Czech medicinal plants.

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  • Additional Information
    • Source:
      Publisher: Elsevier Sequoia Country of Publication: Ireland NLM ID: 7903310 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7573 (Electronic) Linking ISSN: 03788741 NLM ISO Abbreviation: J Ethnopharmacol Subsets: MEDLINE
    • Publication Information:
      Publication: Limerick : Elsevier Sequoia
      Original Publication: Lausanne, Elsevier Sequoia.
    • Subject Terms:
      Betula*/metabolism ; Populus*; Enzyme Inhibitors/*pharmacology ; Plant Extracts/*pharmacology ; Xanthine Oxidase/*antagonists & inhibitors; Czech Republic ; Ethnopharmacology ; Flavonoids/analysis ; Flavonoids/pharmacology ; Phenols/analysis ; Phenols/pharmacology ; Plants, Medicinal ; Polyphenols
    • Abstract:
      Aim of the Study: To investigate in vitro xanthine oxidase inhibitory properties of plants traditionally used in Czech Republic and Central-East Europe region for gout, arthritis or rheumatism treatment.
      Materials and Methods: Methylene chloride-methanolic and two ethanolic extracts of 27 plant species were screened for in vitro xanthine oxidase inhibitory activity using a spectrophotometric method.
      Results: Around 50% of the species exhibited some degree of xanthine oxidase inhibitory properties at 200 μg/mL, showing a moderate correlation (r=0.59) with total phenol content. The most active were methylene chloride-methanolic extracts of Populus nigra and Betula pendula, with IC(50) of 8.3 and 25.9 μg/mL, respectively, followed by 80% ethanolic extract of Caryophyllus aromaticus and Hypericum perforatum, both under 50 μg/mL.
      Conclusions: Populus nigra and Betula pendula were identified as species with the highest xanthine oxidase inhibitory potential in our study. This correlates with the ethnobotanical data on their use in Central European folklore and provides the basis for further investigation on these plants.
      (Copyright © 2010 Elsevier Ireland Ltd. All rights reserved.)
    • Accession Number:
      0 (Enzyme Inhibitors)
      0 (Flavonoids)
      0 (Phenols)
      0 (Plant Extracts)
      0 (Polyphenols)
      EC 1.17.3.2 (Xanthine Oxidase)
    • Publication Date:
      Date Created: 20100831 Date Completed: 20110511 Latest Revision: 20111117
    • Publication Date:
      20221213
    • Accession Number:
      10.1016/j.jep.2010.08.044
    • Accession Number:
      20800669