Aseptic meningitis after intrathecal baclofen injection.

Study design:Two case reports of aseptic meningitis after intrathecal baclofen injection.Objectives:To report an unusual complication of intrathecal baclofen injection during test injections.Setting:Department of Neurological Rehabilitation, R Poincaré Hôpital (Paris-Ile de France-Ouest University).Case reports:We present two cases of chemical meningitis after intrathecal baclofen injections by lumbar puncture. These cases presented with febrile meningeal syndromes during the 24 h following intrathecal baclofen injection. Direct cerebrospinal fluid (CSF) examination and CSF cultures were negative. An intense cellular reaction was observed with a marked predominance of neutrophils. Meningitis resolved spontaneously over 3–4 days.Conclusions:Chemical meningitis is a rare complication of intrathecal baclofen injections that must be recognized. It is a diagnosis of exclusion and its pathophysiological mechanism remains unclear.Spinal Cord (2006) 44, 330–333. doi:10.1038/sj.sc.3101838; published online 20 September 2005 [ABSTRACT FROM AUTHOR]

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