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Light-Dependent Sequestration of TIMELESS by CRYPTOCHROME.
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- Author(s): Ceriani, M. Fernanda; Darlington, Thomas K.; Staknis, David; Mas, Paloma; Petti, Allegra A.; Weitz, Charles J.; Kay, Steve A.
- Source:
Science. 7/23/1999, Vol. 285 Issue 5427, p553-556. 4p. 9 Color Photographs, 3 Black and White Photographs, 2 Graphs.
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- Abstract:
Presents a study where CRYPTOCHROME (CRY), a protein involved in circadian photoperception in Drosophila, is shown to block the function of PERIOD/TIMELESS (PER/TIM) heterodimeric complexes in a light-dependent fashion. Uncoupling of TIM degradation from abrogation of its function by light; Direct interaction of CRY and TIM in yeast in a light-dependent fashion; Influence of PER/TIM and CRY on the subcellular distribution of these protein complexes; Conclusion that CRY act as a circadian photoreceptor.
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