Multiply expressed tRNA genes?

Publisher: Taylor & Francis Country of Publication: England NLM ID: 8404176 Publication Model: Print Cited Medium: Internet ISSN: 1538-0254 (Electronic) Linking ISSN: 07391102 NLM ISO Abbreviation: J Biomol Struct Dyn Subsets: MEDLINE

Publication: June 2012- : Oxon, UK : Taylor & Francis
Original Publication: Guilderland, NY : Adenine Press, [c1983-

Computer Simulation* ; Gene Expression*; RNA, Transfer/*genetics; Base Sequence ; Introns ; Methanococcus/genetics ; Molecular Sequence Data

Some coding (mRNA) genes are known to express into several different amino-acid chains by intron and exon shuffling. There are computational arguments that an analogous mechanism may give rise to two different products from a single non-coding gene. We propose, based on bioinformatics' evidence, that the number of different products from some of these non-coding genes may indeed be greater than two. The present study demonstrates that, in some cases, intron repositioning and partial exon-intron shuffling lead to newer putative tRNAs. An intricate and entangled organizational network performs a complex optimization of the secondary structures at the exon-intron boundaries. We find up to four different RNAs are encoded cryptically in a single composite tRNA gene. But it is the remarkably high fidelity of the secondary structures and the conserved sequences of all the tRNAs that are embedded that leads to this hypothesis.

9014-25-9 (RNA, Transfer)

Date Created: 20100722 Date Completed: 20101029 Latest Revision: 20100721

20221213

10.1080/07391102.2010.10507356

20645656