Item request has been placed!
×
Item request cannot be made.
×
Processing Request
[Synchronous detection of T-cell clonality and FIP1L1-PDGFRA fusion gene in a hypereosinophilic syndrome].
Item request has been placed!
×
Item request cannot be made.
×
Processing Request
- Additional Information
- Transliterated Title:
Détection simultanée d'une clonalité T et d'un transcrit FIP1L1-PDGFRA au cours d'un syndrome hyperéosinophilique.
- Source:
Publisher: Elsevier Country of Publication: France NLM ID: 8101383 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3122 (Electronic) Linking ISSN: 02488663 NLM ISO Abbreviation: Rev Med Interne Subsets: MEDLINE
- Publication Information:
Publication: Paris : Elsevier
Original Publication: Paris : Baillière, [1980-
- Subject Terms:
- Abstract:
We report a 49-year-old man suffering from chronic hypereosinophilia whose biological tests revealed a gene rearrangement between FIP1L1 and PDGFRA as well as a T-cell clonality. After 1 year of therapy with imatinib mesylate (100 mg daily), the patient was clinically asymptomatic, the fusion transcript was undetectable using RTQ-PCR and no lymphoproliferative disorders occurred. This unique combination raises the question of the physiopathology of such a grey zone hypereosinophilia and their management.
(Copyright © 2010. Published by Elsevier SAS.)
- Accession Number:
0 (Antineoplastic Agents)
0 (Benzamides)
0 (FIP1L1 protein, human)
0 (Oncogene Proteins, Fusion)
0 (Piperazines)
0 (Pyrimidines)
0 (mRNA Cleavage and Polyadenylation Factors)
8A1O1M485B (Imatinib Mesylate)
EC 2.7.10.1 (Receptor, Platelet-Derived Growth Factor alpha)
- Publication Date:
Date Created: 20100717 Date Completed: 20110930 Latest Revision: 20161018
- Publication Date:
20231215
- Accession Number:
10.1016/j.revmed.2010.06.003
- Accession Number:
20633965
No Comments.