[Histological and immunohistochemical characteristics of stimulated angiogenesis in transplantation of multipotent stem cells derived from the adipose tissue in patients with chronic ischemia of the extremities].

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  • Additional Information
    • Source:
      Publisher: Ministerstvo Okhorony Zdorovia Ukrainy Country of Publication: Ukraine NLM ID: 9516872 Publication Model: Print Cited Medium: Print ISSN: 0023-2130 (Print) Linking ISSN: 00232130 NLM ISO Abbreviation: Klin Khir Subsets: MEDLINE
    • Publication Information:
      Publication: Kyiv : Ministerstvo Okhorony Zdorovia Ukrainy
      Original Publication: Kyïv : [s.n.], c1995-
    • Subject Terms:
      Neovascularization, Physiologic*; Adipose Tissue/*cytology ; Ischemia/*surgery ; Leg/*blood supply ; Multipotent Stem Cells/*transplantation ; Stem Cell Transplantation/*methods; Adult ; Chronic Disease ; Collagen Type IV/biosynthesis ; Female ; Fibrosis ; Humans ; Immunohistochemistry ; Ischemia/metabolism ; Ischemia/pathology ; Leg/surgery ; Male ; Transplantation, Autologous ; Treatment Outcome ; Vimentin/biosynthesis ; von Willebrand Factor/biosynthesis
    • Abstract:
      The cellular technologies application with the objective for the processes of angiogenesis stimulation, in the ischemia conditions, constitutes an actual task for modern stage of a science development, the discovery of a new sources of cells-stimulants for neoangiogenesis is in a progress. The investigation was performed with an objective of studying of histological and immunohistochemical changes in muscular tissue, occurring after autotransplantation of multipotent stromal cells from adipose tissue of the patients, suffering the extremity ischemia. Histological and immunohistochemical investigations (detection of antibodies expression towards Villebrand factor, collagen type IV and vimentin) of processes, occurring in muscular tissue after introduction of multipotent stromal cells from adipose tissue of this patient, were conducted. The reduction of myofibrils ischemic affection and rapid activation of the muscle regenerative potential were shown. There was established a vivid stimulation of the angiogenesis processes during already first month after cellular transplantation performance.
    • Accession Number:
      0 (Collagen Type IV)
      0 (Vimentin)
      0 (von Willebrand Factor)
    • Publication Date:
      Date Created: 20100714 Date Completed: 20100820 Latest Revision: 20161018
    • Publication Date:
      20231215
    • Accession Number:
      20623978