[The virtual infected cell: a systems biology rational for antiviral drug discovery].

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  • Additional Information
    • Transliterated Title:
      La cellule infectée virtuelle : un rationnel de biologie systémique pour la découverte de nouvelles cibles thérapeutiques antivirales.
    • Source:
      Publisher: EDK Country of Publication: France NLM ID: 8710980 Publication Model: Print Cited Medium: Print ISSN: 0767-0974 (Print) Linking ISSN: 07670974 NLM ISO Abbreviation: Med Sci (Paris) Subsets: MEDLINE
    • Publication Information:
      Publication: <2003->: Paris : EDK
      Original Publication: [Paris] : Flammarion, [1985-
    • Subject Terms:
      User-Computer Interface*; Antiviral Agents/*chemical synthesis ; Antiviral Agents/*therapeutic use ; Virus Diseases/*genetics; Genome, Viral ; Humans ; Models, Genetic ; Proteome ; Viral Proteins/genetics ; Virus Diseases/drug therapy ; Viruses/genetics
    • Abstract:
      Infection caused by pathogens kills millions of people every year. Comprehensive understanding of molecular pathogen-host interactions, i.e. the infectome, is one of the key steps towards the development of novel diagnostic, therapeutic and preventive strategies. In this quest, progress in high-throughput << omics >> technologies applied to pathogens, i.e. infectomics, opens new perspectives toward systemic understanding of perturbations induced during infection. Deciphering the pathogen-host system also relies on the analytical and predictive power of molecular systems biology and by developing in silico models taking into account the whole picture of the molecules and their interactions. In this context, we have reconstructed a prototype of the human virtual infected cell based on 30 years of intensive research in the field of molecular virology. This model contains more than one hundred viral infectomes, including major human pathogens (HCV, HBV, HIV, HHV, HPV) and has led to the generation of novel systems-level hypotheses that could be suitable for the development of innovative antiviral strategies based on the control of cellular functions.
    • Number of References:
      35
    • Comments:
      Comment in: Med Sci (Paris). 2010 Jun-Jul;26(6-7):559-60. (PMID: 20619148)
    • Accession Number:
      0 (Antiviral Agents)
      0 (Proteome)
      0 (Viral Proteins)
    • Publication Date:
      Date Created: 20100713 Date Completed: 20100923 Latest Revision: 20100712
    • Publication Date:
      20221213
    • Accession Number:
      10.1051/medsci/2010266-7603
    • Accession Number:
      20619162