Serum levels of proamylin and amylin in normal subjects and patients with impaired glucose regulation and type 2 diabetes mellitus.

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
Read More Add to Saved list
  • Author(s): Zheng X;Zheng X; Ren W; Zhang S; Liu J; Li S; Li J; Yang P; He J; Su S; Li P
  • Source:
    Acta diabetologica [Acta Diabetol] 2010 Sep; Vol. 47 (3), pp. 265-70. Date of Electronic Publication: 2010 May 28.
  • Publication Type:
    Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Springer Verlag Country of Publication: Germany NLM ID: 9200299 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-5233 (Electronic) Linking ISSN: 09405429 NLM ISO Abbreviation: Acta Diabetol Subsets: MEDLINE
    • Publication Information:
      Publication: Berlin : Springer Verlag
      Original Publication: Berlin : Springer International, c1991-
    • Subject Terms:
      Insulin Resistance*/physiology; Diabetes Mellitus, Type 2/*blood ; Glucose Intolerance/*blood ; Islet Amyloid Polypeptide/*blood ; Protein Precursors/*blood; Adult ; Aged ; Blood Glucose/analysis ; Blood Glucose/metabolism ; Body Composition/physiology ; Diabetes Mellitus, Type 2/diagnosis ; Diabetes Mellitus, Type 2/metabolism ; Diabetes Mellitus, Type 2/physiopathology ; Female ; Glucose Intolerance/complications ; Glucose Intolerance/metabolism ; Glucose Intolerance/physiopathology ; Glucose Tolerance Test ; Humans ; Islet Amyloid Polypeptide/analysis ; Lipids/blood ; Male ; Middle Aged ; Protein Precursors/analysis ; Serum/chemistry ; Serum/metabolism
    • Abstract:
      Amylin is the major constituent of pancreatic islet amyloid whose accumulation characterizes patients with type 2 diabetes mellitus (T2DM). Although amylin is tightly linked with T2DM, in many cases, proamylin may be the more toxic species. As the precursor of amylin, however, the pathophysiological role of proamylin remains unknown. In this study, we investigate whether serum levels of proamylin or amylin or the proamylin/amylin ratios are different among normal subjects and patients with impaired glucose regulation (IGR) and T2DM. Totally 79 subjects were divided into three groups according to the results of oral glucose tolerance test (OGTT); they were T2DM group (32 cases), IGR group (23cases), and normal glucose tolerance (NGT) group (24cases). Serum levels of amylin and proamylin were measured with an enzyme-linked immunosorbent assay (ELISA). The relationships between serum levels of proamylin, amylin, their ratios and anthropometric and metabolic parameters were also analyzed. The serum levels of proamylin were significantly higher in patients with IGR and T2DM than in control subjects. The serum levels of proamylin were significantly associated with IGR and T2DM, with the odds ratios of 1.589 (95%CI, 1.228-2.055, P < 0.01) and 1.860 (95%CI, 1.342-2.587, P < 0.01), respectively. Both fasting serum levels of proamylin and proamylin/amylin ratios were found to correlate negatively with HOMA-B and DeltaI30/DeltaG30. Serum levels of proamylin, amylin, and their ratios were positively correlated with HOMA-IR. BMI and HOMA-B were independent related factors with serum levels of proamylin. Our results suggest that proamylin may play an important role in amyloid deposit in patients with IGR and T2DM.
    • Accession Number:
      0 (Blood Glucose)
      0 (Islet Amyloid Polypeptide)
      0 (Lipids)
      0 (Protein Precursors)
    • Publication Date:
      Date Created: 20100529 Date Completed: 20101202 Latest Revision: 20100727
    • Publication Date:
      20231215
    • Accession Number:
      10.1007/s00592-010-0201-9
    • Accession Number:
      20509034