Effect of antibiotics on food intake and absorption of nutrients for children with diarrhea due to Shigella.

Publisher: University Of Chicago Press Country of Publication: United States NLM ID: 7905878 Publication Model: Print Cited Medium: Print ISSN: 0162-0886 (Print) Linking ISSN: 01620886 NLM ISO Abbreviation: Rev Infect Dis Subsets: MEDLINE

Publication: Chicago Il : University Of Chicago Press
Original Publication: Chicago, Univ. of Chicago Press.

Anti-Bacterial Agents/*therapeutic use ; Diarrhea/*metabolism ; Dysentery, Bacillary/*metabolism ; Eating/*drug effects ; Intestinal Absorption/*drug effects; Acute Disease ; Anti-Bacterial Agents/pharmacology ; Child, Preschool ; Diarrhea/drug therapy ; Dietary Carbohydrates/administration & dosage ; Dietary Carbohydrates/metabolism ; Dietary Fats/administration & dosage ; Dietary Fats/metabolism ; Dysentery, Bacillary/drug therapy ; Electrolytes/blood ; Energy Intake ; Erythrocyte Count ; Feces/cytology ; Humans ; Infant ; Leukocyte Count ; Male ; Nitrogen/administration & dosage ; Nitrogen/metabolism

The effect of antibiotic therapy on intake of food and absorption of nutrients for 19 male children aged 1-5 years with suspected shigella infection was studied. The children were admitted to the hospital with acute diarrhea, high fever, abdominal pain, and greater than or equal to 25 red blood cells and white blood cells per high-power field in the stool. Microbiologic diagnosis was made within 48 hours of admission. On the basis of clinical and microbiologic criteria, children were classified as having mild or severe infection. Ten children with mild infection did not receive antibiotics, whereas nine children with severe infection were treated with ampicillin. After the children were rehydrated, a 72-hour balance study was carried out during the acute stage of infection with Shigella and was repeated 2 weeks after recovery. The levels of consumption of food and absorption of nutrients were estimated. During the acute stage of infection, such levels were higher for the children treated with antibiotics than for the untreated group. During the recovery phase, the levels of intake of food and absorption of nutrients were equal for both groups. Thus, children who are treated with appropriate antibiotics not only may recover from infection with Shigella more rapidly, but they also may be able to absorb nutrients more efficiently.

0 (Anti-Bacterial Agents)
0 (Dietary Carbohydrates)
0 (Dietary Fats)
0 (Electrolytes)
N762921K75 (Nitrogen)

Date Created: 19910301 Date Completed: 19910717 Latest Revision: 20190828

20250114

10.1093/clinids/13.supplement_4.s347

2047661