Comparative testing of new hemostatic agents in a swine model of extremity arterial and venous hemorrhage.

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  • Author(s): Clay JG;Clay JG; Grayson JK; Zierold D
  • Source:
    Military medicine [Mil Med] 2010 Apr; Vol. 175 (4), pp. 280-4.
  • Publication Type:
    Comparative Study; Journal Article
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Oxford University Press Country of Publication: England NLM ID: 2984771R Publication Model: Print Cited Medium: Print ISSN: 0026-4075 (Print) Linking ISSN: 00264075 NLM ISO Abbreviation: Mil Med Subsets: MEDLINE
    • Publication Information:
      Publication: 2018- : Oxford : Oxford University Press
      Original Publication: Washington, D.C. : Association of Military Surgeons, United States, 1955-
    • Subject Terms:
      Hemostatics*/therapeutic use; Blood Loss, Surgical/*prevention & control; Animals ; Biopolymers ; Chitosan ; Disease Models, Animal ; Female ; Male ; Sus scrofa
    • Abstract:
      Objective: To compare advanced hemostatic dressings: HemCon (HC), QuikClot ACS+ (advanced clotting sponge, and two granular agents: Celox (CX) and WoundStat (WS), with a standard field dressing in a swine model of extremity hemorrhage.
      Methods: We randomized 30 animals to treatment with a standard dressing or a hemostatic agent applied to a 2 x 6-mm injury in the femoral artery and vein after 45 s of free bleeding. Animals received 500 mL Hextend 15 min after the bleeding commenced without further resuscitation. End point was survival to 120 min or non-survivable blood pressure.
      Results: Survival to 120 min among treatment groups was 100% (WS), 83% (CX), 67% (HC), and 50% (ACS+). No control animals survived. Postinjury blood loss (mL/kg) was 4.6 (WS), 12.9 (CX), 10.0 (HC), and 15.8 (ACS+) compared to 27.0 for controls.
      Conclusion: All hemostatic dressings result in significantly less blood loss and improved survival over standard gauze dressing.
    • Accession Number:
      0 (Biopolymers)
      0 (Celox)
      0 (Hemostatics)
      9012-76-4 (Chitosan)
    • Publication Date:
      Date Created: 20100508 Date Completed: 20100614 Latest Revision: 20190513
    • Publication Date:
      20240829
    • Accession Number:
      10.7205/milmed-d-09-00185
    • Accession Number:
      20446504