Development and organization of polarity-specific segregation of primary vestibular afferent fibers in mice.

Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 0417625 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-0878 (Electronic) Linking ISSN: 0302766X NLM ISO Abbreviation: Cell Tissue Res Subsets: MEDLINE

Original Publication: Berlin, New York, Springer-Verlag.

Cell Polarity*/drug effects; Afferent Pathways/*cytology ; Vestibule, Labyrinth/*cytology ; Vestibule, Labyrinth/*innervation; Afferent Pathways/drug effects ; Afferent Pathways/metabolism ; Animals ; Animals, Newborn ; Brain Stem/cytology ; Brain Stem/drug effects ; Brain Stem/metabolism ; Embryo, Mammalian/cytology ; Embryo, Mammalian/drug effects ; Embryo, Mammalian/metabolism ; Mice ; Neuronal Tract-Tracers/pharmacology ; Vestibule, Labyrinth/drug effects

A striking feature of vestibular hair cells is the polarized arrangement of their stereocilia as the basis for their directional sensitivity. In mammals, each of the vestibular end organs is characterized by a distinct distribution of these polarized cells. We utilized the technique of post-fixation transganglionic neuronal tracing with fluorescent lipid soluble dyes in embryonic and postnatal mice to investigate whether these polarity characteristics correlate with the pattern of connections between the endorgans and their central targets; the vestibular nuclei and cerebellum. We found that the cerebellar and brainstem projections develop independently from each other and have a non-overlapping distribution of neurons and afferents from E11.5 on. In addition, we show that the vestibular fibers projecting to the cerebellum originate preferentially from the lateral half of the utricular macula and the medial half of the saccular macula. In contrast, the brainstem vestibular afferents originate primarily from the medial half of the utricular macula and the lateral half of the saccular macula. This indicates that the line of hair cell polarity reversal within the striola region segregates almost mutually exclusive central projections. A possible interpretation of this feature is that this macular organization provides an inhibitory side-loop through the cerebellum to produce synergistic tuning effects in the vestibular nuclei. The canal cristae project to the brainstem vestibular nuclei and cerebellum, but the projection to the vestibulocerebellum originates preferentially from the superior half of each of the cristae. The reason for this pattern is not clear, but it may compensate for unequal activation of crista hair cells or may be an evolutionary atavism reflecting a different polarity organization in ancestral vertebrate ears.

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R01 DC005590 United States DC NIDCD NIH HHS

0 (Neuronal Tract-Tracers)

Date Created: 20100429 Date Completed: 20100721 Latest Revision: 20211020

20240829

PMC2953634

10.1007/s00441-010-0944-1

20424840