Dally cooperates with Drosophila Frizzled 2 to transduce Wingless signalling.

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  • Author(s): Lin, Xinhua; Perrimon, Norbert
  • Source:
    Nature. 7/15/1993, Vol. 400 Issue 6741, p281. 4p. 3 Color Photographs, 30 Black and White Photographs.
  • Additional Information
    • Subject Terms:
      DROSOPHILA genetics; GENE expression; PROTEOGLYCANS; GENES; GENETICS; PHYSIOLOGY
    • Abstract:
      Demonstrates that the Drosophila gene sulfateless (sfl), which encodes a homologue of vertebrate heparan sulphate N-deacetylase/N-sulphotransferase is essential for the wingless gene (Wg) signalling. Identification of the product of division abnormally delayed (dally), a glycosyl-phosphatidyl inositol (GPI)-linked glypican, as a heparan sulphate proteoglycan molecule involved in Wg signaling; Indication that dally may act as a co-receptor for Wg, and together with D.Frizzled 2, modulates short-and long-range activities of Wg.