Particular HLA-DQ alpha beta heterodimer associated with IDDM susceptibility in both DR4-DQw4 Japanese and DR4-DQw8/DRw8-DQw4 whites.

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  • Additional Information
    • Source:
      Publisher: American Diabetes Association Country of Publication: United States NLM ID: 0372763 Publication Model: Print Cited Medium: Print ISSN: 0012-1797 (Print) Linking ISSN: 00121797 NLM ISO Abbreviation: Diabetes Subsets: MEDLINE
    • Publication Information:
      Publication: Alexandria, VA : American Diabetes Association
      Original Publication: [New York, American Diabetes Association]
    • Subject Terms:
      Diabetes Mellitus, Type 1/*immunology ; HLA-DQ Antigens/*genetics ; HLA-DR Antigens/*genetics ; HLA-DR4 Antigen/*genetics; Alleles ; Asian People ; B-Lymphocytes/immunology ; Cell Line ; Diabetes Mellitus, Type 1/genetics ; Disease Susceptibility/immunology ; Genetic Predisposition to Disease ; HLA-DR Serological Subtypes ; Haplotypes ; Humans ; Japan/ethnology ; Lymphocyte Activation ; Macromolecular Substances ; Norway ; T-Lymphocytes/immunology ; White People
    • Abstract:
      Insulin-dependent diabetes mellitus (IDDM) susceptibility is associated with the DR4-DQw4 haplotype in Japanese and the DR4-DQw8/-Drw8-DQw4 genotype (among others) in whites. We investigated whether these Japanese and white individuals encode the same or a similar DQ alpha beta heterodimer, which may be an IDDM-susceptibility molecule in both populations. First, we carried out genomic DQA1 and DQB1 typing with sequence-specific oligonucleotide probes. The results revealed that Japanese DR4-DQw4 and white DR4-DQw8/DRw8-DQw4 IDDM patients carried the DQA1*0301 allele and the DQB1*0401 or DQB1*0402 allele, either in the cis (Japanese DR4-DQw4 individuals) or trans (white DR4-DQw8/DRw8-DQw4 individuals) position. Because the DQB1*0401 and DQB1*0402 alleles differ only at residue 23, these DQB1 genes are very similar. We next tested cells from these individuals with a particular DQ-specific T-lymphocyte clone, HH58. The clone was only restimulated with cells from Japanese individuals who carried the DQA1*0301 and DQB1*0401 alleles in the cis position or white individuals who carried the DQA1*0301 and DQB1*0402 alleles in the trans position. Thus, particular cis- or trans-encoded DQ alpha beta heterodimers, which in both cases are recognized by T lymphocytes, may confer susceptibility to IDDM in both ethnic groups.
    • Accession Number:
      0 (HLA-DQ Antigens)
      0 (HLA-DQ4 antigen)
      0 (HLA-DQ8 antigen)
      0 (HLA-DR Antigens)
      0 (HLA-DR Serological Subtypes)
      0 (HLA-DR4 Antigen)
      0 (HLA-DR8 antigen)
      0 (Macromolecular Substances)
    • Publication Date:
      Date Created: 19910601 Date Completed: 19910710 Latest Revision: 20221207
    • Publication Date:
      20221208
    • Accession Number:
      10.2337/diab.40.6.759
    • Accession Number:
      2040392